STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
fdhDRequired for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH. (279 aa)    
Predicted Functional Partners:
DR97_2549
Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
  
 0.981
fdhA
Catalyzes the NAD(+)-dependent oxidation of formaldehyde and acetoaldehyde
      
 0.858
DR97_2346
annotation not available
     
 0.853
rhdA
Catalyzes the sulfur transfer reaction from thiosulfate to cyanide, thus converting cyanide to the less toxic thiocyanate . Contributes to P.aeruginosa survival under cyanogenic conditions, and thus provides the bacterium with a defense mechanism against endogenous cyanide toxicity . Is the main cytoplasmic rhodanese in P.aeruginosa, accounting for 90% of total rhodanese activity
      
 0.845
ModR
Molybdenum transport regulator; modE_repress: ModE molybdate transport repressor domain protein
 
  
 0.831
fdnG
formate-DH-alph: formate dehydrogenase, alpha subunit; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
 
 
 0.830
DR97_5245
Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
 
 
 0.816
DR97_2547
Belongs to the LysR transcriptional regulatory family.
 
     0.765
fdhE
Necessary for formate dehydrogenase activity.
 
 
 
 0.738
purH
Bifunctional purine biosynthesis protein PurH; purH: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase
      
 0.695
Your Current Organism:
Pseudomonas aeruginosa
NCBI taxonomy Id: 287
Other names: ATCC 10145, ATCC 10145-U, Bacillus aeruginosus, Bacillus pyocyaneus, Bacterium aeruginosum, Bacterium pyocyaneum, CCEB 481, CCUG 28447, CCUG 29297, CCUG 551, CFBP 2466, CIP 100720, DSM 50071, IBCS 277, IFO 12689, JCM 5962, Micrococcus pyocyaneus, NBRC 12689, NCCB 76039, NCIB 8295, NCIMB 8295, NCTC 10332, NRRL B-771, P. aeruginosa, Pseudomonas polycolor, Pseudomonas pyocyanea, Pseudomonas sp. RV3, RH 815, VKM B-588, bacterium ASFP-37, bacterium ASFP-38, bacterium ASFP-45, bacterium ASFP-46, bacterium ASFP-48
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