cyaA protein (Pseudomonas aeruginosa) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
some 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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[Homology]

Score

cyaA

annotation not available (950 aa)

Predicted Functional Partners:

cpdA

0.993

cyaB

0.971

vfr

0.939

pykF

0.912

relA

0.906

pykA

0.906

rpoZ

0.904

rpoC

0.904

mazG

0.903

spoT

0.902

Your Current Organism:

Pseudomonas aeruginosa

NCBI taxonomy Id: 287
Other names: ATCC 10145, ATCC 10145-U, Bacillus aeruginosus, Bacillus pyocyaneus, Bacterium aeruginosum, Bacterium pyocyaneum, CCEB 481, CCUG 28447, CCUG 29297, CCUG 551, CFBP 2466, CIP 100720, DSM 50071, IBCS 277, IFO 12689, JCM 5962, Micrococcus pyocyaneus, NBRC 12689, NCCB 76039, NCIB 8295, NCIMB 8295, NCTC 10332, NRRL B-771, P. aeruginosa, Pseudomonas aeruginosa, Pseudomonas polycolor, Pseudomonas pyocyanea, Pseudomonas sp. RV3, RH 815, VKM B-588, bacterium ASFP-37, bacterium ASFP-38, bacterium ASFP-45, bacterium ASFP-46, bacterium ASFP-48

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structured XML interaction data, according to the 'PSI-MI' data standard

... network coordinates:

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a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and annotated functions of the network proteins

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
cpdA	cyaA	DR97_2322	DR97_2643	3’,5’-cyclic adenosine monophosphate phosphodiesterase CpdA; Hydrolyzes cAMP to 5’-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes. Specifically required for regulation of virulence factors. Can also hydrolyze cGMP; Belongs to the cAMP phosphodiesterase class-III family	annotation not available	0.993
cpdA	cyaB	DR97_2322	DR97_4717	3’,5’-cyclic adenosine monophosphate phosphodiesterase CpdA; Hydrolyzes cAMP to 5’-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes. Specifically required for regulation of virulence factors. Can also hydrolyze cGMP; Belongs to the cAMP phosphodiesterase class-III family	annotation not available	0.989
cpdA	mazG	DR97_2322	DR97_1004	3’,5’-cyclic adenosine monophosphate phosphodiesterase CpdA; Hydrolyzes cAMP to 5’-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes. Specifically required for regulation of virulence factors. Can also hydrolyze cGMP; Belongs to the cAMP phosphodiesterase class-III family	Nucleoside triphosphate pyrophosphohydrolase; mazG- MazG family protein	0.922
cpdA	vfr	DR97_2322	DR97_3605	3’,5’-cyclic adenosine monophosphate phosphodiesterase CpdA; Hydrolyzes cAMP to 5’-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes. Specifically required for regulation of virulence factors. Can also hydrolyze cGMP; Belongs to the cAMP phosphodiesterase class-III family	annotation not available	0.937
cyaA	cpdA	DR97_2643	DR97_2322	annotation not available	3’,5’-cyclic adenosine monophosphate phosphodiesterase CpdA; Hydrolyzes cAMP to 5’-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes. Specifically required for regulation of virulence factors. Can also hydrolyze cGMP; Belongs to the cAMP phosphodiesterase class-III family	0.993
cyaA	cyaB	DR97_2643	DR97_4717	annotation not available	annotation not available	0.971
cyaA	mazG	DR97_2643	DR97_1004	annotation not available	Nucleoside triphosphate pyrophosphohydrolase; mazG- MazG family protein	0.903
cyaA	pykA	DR97_2643	DR97_1505	annotation not available	Pyruv_kin- pyruvate kinase; Belongs to the pyruvate kinase family	0.906
cyaA	pykF	DR97_2643	DR97_524	annotation not available	Pyruv_kin- pyruvate kinase; Belongs to the pyruvate kinase family	0.912
cyaA	relA	DR97_2643	DR97_1005	annotation not available	GTP pyrophosphokinase; In eubacteria ppGpp (guanosine 3’-diphosphate 5-’ diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance	0.906
cyaA	rpoC	DR97_2643	DR97_3642	annotation not available	DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	0.904
cyaA	rpoZ	DR97_2643	DR97_2708	annotation not available	DNA-directed RNA polymerase subunit omega; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta’ subunit thereby facilitating its interaction with the beta and alpha subunits	0.904
cyaA	spoT	DR97_2643	DR97_2709	annotation not available	Guanosine-3’,5’-bis(Diphosphate) 3’-pyrophosphohydrolase; In eubacteria ppGpp (guanosine 3’-diphosphate 5-’ diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance	0.902
cyaA	vfr	DR97_2643	DR97_3605	annotation not available	annotation not available	0.939
cyaB	cpdA	DR97_4717	DR97_2322	annotation not available	3’,5’-cyclic adenosine monophosphate phosphodiesterase CpdA; Hydrolyzes cAMP to 5’-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes. Specifically required for regulation of virulence factors. Can also hydrolyze cGMP; Belongs to the cAMP phosphodiesterase class-III family	0.989
cyaB	cyaA	DR97_4717	DR97_2643	annotation not available	annotation not available	0.971
cyaB	mazG	DR97_4717	DR97_1004	annotation not available	Nucleoside triphosphate pyrophosphohydrolase; mazG- MazG family protein	0.900
cyaB	pykA	DR97_4717	DR97_1505	annotation not available	Pyruv_kin- pyruvate kinase; Belongs to the pyruvate kinase family	0.913
cyaB	pykF	DR97_4717	DR97_524	annotation not available	Pyruv_kin- pyruvate kinase; Belongs to the pyruvate kinase family	0.913
cyaB	relA	DR97_4717	DR97_1005	annotation not available	GTP pyrophosphokinase; In eubacteria ppGpp (guanosine 3’-diphosphate 5-’ diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance	0.901

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