node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DR97_3849 | mpl | DR97_3849 | DR97_3847 | Conserved hypothetical protein | Udp-n-acetylmuramate: l-alanyl-gamma-d-glutamyl-meso-diaminopimelate ligase; Reutilizes the intact tripeptide L-alanyl-gamma-D-glutamyl- meso-diaminopimelate by linking it to UDP-N-acetylmuramate | 0.862 |
DR97_3849 | ubiX | DR97_3849 | DR97_3848 | Conserved hypothetical protein | Polyprenyl p-hydroxybenzoate and phenylacrylic acid decarboxylase family protein; Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN | 0.872 |
ampD | anmK | DR97_1701 | DR97_3619 | annotation not available | Anhydro-n-acetylmuramic acid kinase; Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P (By similarity). Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling. Contributes to intrinsic fosfomycin resistance in P.aeruginosa | 0.879 |
ampD | ftsI | DR97_1701 | DR97_1596 | annotation not available | Cell division protein ftsi (penicillin-binding protein 3); Catalyzes cross-linking of the peptidoglycan cell wall at the division septum (By similarity). Binds penicillin | 0.546 |
ampD | mpl | DR97_1701 | DR97_3847 | annotation not available | Udp-n-acetylmuramate: l-alanyl-gamma-d-glutamyl-meso-diaminopimelate ligase; Reutilizes the intact tripeptide L-alanyl-gamma-D-glutamyl- meso-diaminopimelate by linking it to UDP-N-acetylmuramate | 0.957 |
ampD | nagZ | DR97_1701 | DR97_4932 | annotation not available | Beta-n-acetylhexosaminidase; Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide- linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N- acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides (By similarity). Contributes to intrinsic fosfomycin resistance in P.aeruginosa | 0.959 |
ampD | pbpC | DR97_1701 | DR97_6161 | annotation not available | Cell division protein ftsi (penicillin-binding protein 3); Catalyzes cross-linking of the peptidoglycan cell wall at the division septum (By similarity). Binds penicillin | 0.546 |
anmK | ampD | DR97_3619 | DR97_1701 | Anhydro-n-acetylmuramic acid kinase; Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P (By similarity). Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling. Contributes to intrinsic fosfomycin resistance in P.aeruginosa | annotation not available | 0.879 |
anmK | mpl | DR97_3619 | DR97_3847 | Anhydro-n-acetylmuramic acid kinase; Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P (By similarity). Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling. Contributes to intrinsic fosfomycin resistance in P.aeruginosa | Udp-n-acetylmuramate: l-alanyl-gamma-d-glutamyl-meso-diaminopimelate ligase; Reutilizes the intact tripeptide L-alanyl-gamma-D-glutamyl- meso-diaminopimelate by linking it to UDP-N-acetylmuramate | 0.949 |
anmK | nagZ | DR97_3619 | DR97_4932 | Anhydro-n-acetylmuramic acid kinase; Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P (By similarity). Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling. Contributes to intrinsic fosfomycin resistance in P.aeruginosa | Beta-n-acetylhexosaminidase; Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide- linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N- acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides (By similarity). Contributes to intrinsic fosfomycin resistance in P.aeruginosa | 0.972 |
ftsI | ampD | DR97_1596 | DR97_1701 | Cell division protein ftsi (penicillin-binding protein 3); Catalyzes cross-linking of the peptidoglycan cell wall at the division septum (By similarity). Binds penicillin | annotation not available | 0.546 |
ftsI | mpl | DR97_1596 | DR97_3847 | Cell division protein ftsi (penicillin-binding protein 3); Catalyzes cross-linking of the peptidoglycan cell wall at the division septum (By similarity). Binds penicillin | Udp-n-acetylmuramate: l-alanyl-gamma-d-glutamyl-meso-diaminopimelate ligase; Reutilizes the intact tripeptide L-alanyl-gamma-D-glutamyl- meso-diaminopimelate by linking it to UDP-N-acetylmuramate | 0.858 |
ftsI | murF | DR97_1596 | DR97_1594 | Cell division protein ftsi (penicillin-binding protein 3); Catalyzes cross-linking of the peptidoglycan cell wall at the division septum (By similarity). Binds penicillin | UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanyl ligase; Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein | 0.982 |
ftsI | pbpC | DR97_1596 | DR97_6161 | Cell division protein ftsi (penicillin-binding protein 3); Catalyzes cross-linking of the peptidoglycan cell wall at the division septum (By similarity). Binds penicillin | Cell division protein ftsi (penicillin-binding protein 3); Catalyzes cross-linking of the peptidoglycan cell wall at the division septum (By similarity). Binds penicillin | 0.809 |
ftsI | polA | DR97_1596 | DR97_2871 | Cell division protein ftsi (penicillin-binding protein 3); Catalyzes cross-linking of the peptidoglycan cell wall at the division septum (By similarity). Binds penicillin | In addition to polymerase activity, this DNA polymerase exhibits 3'-5' and 5'-3' exonuclease activity | 0.502 |
mpl | DR97_3849 | DR97_3847 | DR97_3849 | Udp-n-acetylmuramate: l-alanyl-gamma-d-glutamyl-meso-diaminopimelate ligase; Reutilizes the intact tripeptide L-alanyl-gamma-D-glutamyl- meso-diaminopimelate by linking it to UDP-N-acetylmuramate | Conserved hypothetical protein | 0.862 |
mpl | ampD | DR97_3847 | DR97_1701 | Udp-n-acetylmuramate: l-alanyl-gamma-d-glutamyl-meso-diaminopimelate ligase; Reutilizes the intact tripeptide L-alanyl-gamma-D-glutamyl- meso-diaminopimelate by linking it to UDP-N-acetylmuramate | annotation not available | 0.957 |
mpl | anmK | DR97_3847 | DR97_3619 | Udp-n-acetylmuramate: l-alanyl-gamma-d-glutamyl-meso-diaminopimelate ligase; Reutilizes the intact tripeptide L-alanyl-gamma-D-glutamyl- meso-diaminopimelate by linking it to UDP-N-acetylmuramate | Anhydro-n-acetylmuramic acid kinase; Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P (By similarity). Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling. Contributes to intrinsic fosfomycin resistance in P.aeruginosa | 0.949 |
mpl | ftsI | DR97_3847 | DR97_1596 | Udp-n-acetylmuramate: l-alanyl-gamma-d-glutamyl-meso-diaminopimelate ligase; Reutilizes the intact tripeptide L-alanyl-gamma-D-glutamyl- meso-diaminopimelate by linking it to UDP-N-acetylmuramate | Cell division protein ftsi (penicillin-binding protein 3); Catalyzes cross-linking of the peptidoglycan cell wall at the division septum (By similarity). Binds penicillin | 0.858 |
mpl | murF | DR97_3847 | DR97_1594 | Udp-n-acetylmuramate: l-alanyl-gamma-d-glutamyl-meso-diaminopimelate ligase; Reutilizes the intact tripeptide L-alanyl-gamma-D-glutamyl- meso-diaminopimelate by linking it to UDP-N-acetylmuramate | UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanyl ligase; Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein | 0.853 |