engA protein (Pseudomonas aeruginosa) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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some 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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textmining

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Score

engA

GTPase Der; GTPase that plays an essential role in the late steps of ribosome biogenesis (493 aa)

Predicted Functional Partners:

hisS

0.948

yfgL

0.942

rplA

0.938

rplV

0.919

rplS

0.913

rplD

0.912

rplM

0.900

rplO

0.899

cmk

0.892

rsmH

0.886

Your Current Organism:

Pseudomonas aeruginosa

NCBI taxonomy Id: 287
Other names: ATCC 10145, ATCC 10145-U, Bacillus aeruginosus, Bacillus pyocyaneus, Bacterium aeruginosum, Bacterium pyocyaneum, CCEB 481, CCUG 28447, CCUG 29297, CCUG 551, CFBP 2466, CIP 100720, DSM 50071, IBCS 277, IFO 12689, JCM 5962, Micrococcus pyocyaneus, NBRC 12689, NCCB 76039, NCIB 8295, NCIMB 8295, NCTC 10332, NRRL B-771, P. aeruginosa, Pseudomonas aeruginosa, Pseudomonas polycolor, Pseudomonas pyocyanea, Pseudomonas sp. RV3, RH 815, VKM B-588, bacterium ASFP-37, bacterium ASFP-38, bacterium ASFP-45, bacterium ASFP-46, bacterium ASFP-48

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... protein annotations:

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a tab-delimited file describing the names, domains and annotated functions of the network proteins

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
cmk	engA	DR97_4773	DR97_4070	Cmk: cytidylate kinase; Belongs to the cytidylate kinase family. Type 1 subfamily	GTPase Der; GTPase that plays an essential role in the late steps of ribosome biogenesis	0.892
cmk	hisS	DR97_4773	DR97_4067	Cmk: cytidylate kinase; Belongs to the cytidylate kinase family. Type 1 subfamily	hisS: histidine--tRNA ligase	0.471
cmk	rplS	DR97_4773	DR97_4134	Cmk: cytidylate kinase; Belongs to the cytidylate kinase family. Type 1 subfamily	50S ribosomal protein L19; This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site	0.410
cmk	rplV	DR97_4773	DR97_3653	Cmk: cytidylate kinase; Belongs to the cytidylate kinase family. Type 1 subfamily	50S ribosomal protein L22; The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome	0.558
engA	cmk	DR97_4070	DR97_4773	GTPase Der; GTPase that plays an essential role in the late steps of ribosome biogenesis	Cmk: cytidylate kinase; Belongs to the cytidylate kinase family. Type 1 subfamily	0.892
engA	hisS	DR97_4070	DR97_4067	GTPase Der; GTPase that plays an essential role in the late steps of ribosome biogenesis	hisS: histidine--tRNA ligase	0.948
engA	rplA	DR97_4070	DR97_3638	GTPase Der; GTPase that plays an essential role in the late steps of ribosome biogenesis	50S ribosomal protein L1; Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release	0.938
engA	rplD	DR97_4070	DR97_3649	GTPase Der; GTPase that plays an essential role in the late steps of ribosome biogenesis	50S ribosomal protein L4; Forms part of the polypeptide exit tunnel	0.912
engA	rplM	DR97_4070	DR97_1611	GTPase Der; GTPase that plays an essential role in the late steps of ribosome biogenesis	50S ribosomal protein L13; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly	0.900
engA	rplO	DR97_4070	DR97_3667	GTPase Der; GTPase that plays an essential role in the late steps of ribosome biogenesis	50S ribosomal protein L15; Binds to the 23S rRNA	0.899
engA	rplS	DR97_4070	DR97_4134	GTPase Der; GTPase that plays an essential role in the late steps of ribosome biogenesis	50S ribosomal protein L19; This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site	0.913
engA	rplV	DR97_4070	DR97_3653	GTPase Der; GTPase that plays an essential role in the late steps of ribosome biogenesis	50S ribosomal protein L22; The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome	0.919
engA	rsmH	DR97_4070	DR97_1598	GTPase Der; GTPase that plays an essential role in the late steps of ribosome biogenesis	Ribosomal RNA small subunit methyltransferase H; Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA	0.886
engA	yfgL	DR97_4070	DR97_4069	GTPase Der; GTPase that plays an essential role in the late steps of ribosome biogenesis	Outer membrane protein assembly factor BamB; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	0.942
hisS	cmk	DR97_4067	DR97_4773	hisS: histidine--tRNA ligase	Cmk: cytidylate kinase; Belongs to the cytidylate kinase family. Type 1 subfamily	0.471
hisS	engA	DR97_4067	DR97_4070	hisS: histidine--tRNA ligase	GTPase Der; GTPase that plays an essential role in the late steps of ribosome biogenesis	0.948
hisS	rplD	DR97_4067	DR97_3649	hisS: histidine--tRNA ligase	50S ribosomal protein L4; Forms part of the polypeptide exit tunnel	0.516
hisS	rplM	DR97_4067	DR97_1611	hisS: histidine--tRNA ligase	50S ribosomal protein L13; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly	0.426
hisS	rplV	DR97_4067	DR97_3653	hisS: histidine--tRNA ligase	50S ribosomal protein L22; The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome	0.416
hisS	yfgL	DR97_4067	DR97_4069	hisS: histidine--tRNA ligase	Outer membrane protein assembly factor BamB; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	0.961

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