| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| acrD | macB | DR97_5829 | DR97_6042 | 2A0602- RND transporter, hydrophobe/amphiphile efflux-1 family protein | Macrolide export ATP-binding/permease protein MacB; Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides | 0.894 |
| acrD | oprJ | DR97_5829 | DR97_1903 | 2A0602- RND transporter, hydrophobe/amphiphile efflux-1 family protein | annotation not available | 0.967 |
| acrD | pmpM | DR97_5829 | DR97_434 | 2A0602- RND transporter, hydrophobe/amphiphile efflux-1 family protein | Multidrug resistance protein pmpM; matE- MATE efflux family protein | 0.515 |
| acrD | rnd | DR97_5829 | DR97_500 | 2A0602- RND transporter, hydrophobe/amphiphile efflux-1 family protein | Ribonuclease D; Exonuclease involved in the 3’ processing of various precursor tRNAs. Initiates hydrolysis at the 3’-terminus of an RNA molecule and releases 5’-mononucleotides; Belongs to the RNase D family | 0.870 |
| acrD | tolC_1 | DR97_5829 | DR97_2327 | 2A0602- RND transporter, hydrophobe/amphiphile efflux-1 family protein | type_I_sec_TolC- type I secretion outer membrane , TolC family protein | 0.939 |
| emrE_1 | pmpM | DR97_2344 | DR97_434 | annotation not available | Multidrug resistance protein pmpM; matE- MATE efflux family protein | 0.486 |
| gyrA | oprJ | DR97_4768 | DR97_1903 | DNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner | annotation not available | 0.863 |
| gyrA | pmpM | DR97_4768 | DR97_434 | DNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner | Multidrug resistance protein pmpM; matE- MATE efflux family protein | 0.533 |
| gyrA | rnd | DR97_4768 | DR97_500 | DNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner | Ribonuclease D; Exonuclease involved in the 3’ processing of various precursor tRNAs. Initiates hydrolysis at the 3’-terminus of an RNA molecule and releases 5’-mononucleotides; Belongs to the RNase D family | 0.678 |
| ispH | pmpM | DR97_1861 | DR97_434 | 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis; Belongs to the IspH family | Multidrug resistance protein pmpM; matE- MATE efflux family protein | 0.628 |
| macB | acrD | DR97_6042 | DR97_5829 | Macrolide export ATP-binding/permease protein MacB; Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides | 2A0602- RND transporter, hydrophobe/amphiphile efflux-1 family protein | 0.894 |
| macB | oprJ | DR97_6042 | DR97_1903 | Macrolide export ATP-binding/permease protein MacB; Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides | annotation not available | 0.864 |
| macB | pmpM | DR97_6042 | DR97_434 | Macrolide export ATP-binding/permease protein MacB; Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides | Multidrug resistance protein pmpM; matE- MATE efflux family protein | 0.688 |
| macB | rnd | DR97_6042 | DR97_500 | Macrolide export ATP-binding/permease protein MacB; Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides | Ribonuclease D; Exonuclease involved in the 3’ processing of various precursor tRNAs. Initiates hydrolysis at the 3’-terminus of an RNA molecule and releases 5’-mononucleotides; Belongs to the RNase D family | 0.918 |
| macB | tolC_1 | DR97_6042 | DR97_2327 | Macrolide export ATP-binding/permease protein MacB; Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides | type_I_sec_TolC- type I secretion outer membrane , TolC family protein | 0.964 |
| oprJ | acrD | DR97_1903 | DR97_5829 | annotation not available | 2A0602- RND transporter, hydrophobe/amphiphile efflux-1 family protein | 0.967 |
| oprJ | gyrA | DR97_1903 | DR97_4768 | annotation not available | DNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner | 0.863 |
| oprJ | macB | DR97_1903 | DR97_6042 | annotation not available | Macrolide export ATP-binding/permease protein MacB; Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides | 0.864 |
| oprJ | pmpM | DR97_1903 | DR97_434 | annotation not available | Multidrug resistance protein pmpM; matE- MATE efflux family protein | 0.492 |
| oprJ | rnd | DR97_1903 | DR97_500 | annotation not available | Ribonuclease D; Exonuclease involved in the 3’ processing of various precursor tRNAs. Initiates hydrolysis at the 3’-terminus of an RNA molecule and releases 5’-mononucleotides; Belongs to the RNase D family | 0.874 |
