node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
alg44 | alg8 | DR97_4400 | DR97_4401 | Alginate biosynthesis protein alg44; Required for alginate biosynthesis | Glycosyltransferase like 2 family protein; Processive enzyme that polymerizes GDP-mannuronic acid | 0.999 |
alg44 | algA | DR97_4400 | DR97_4391 | Alginate biosynthesis protein alg44; Required for alginate biosynthesis | Mannose-1-phosphate guanylyltransferase / mannose-6-phosphate isomerase; Produces a precursor for alginate polymerization. The alginate layer provides a protective barrier against host immune defenses and antibiotics | 0.891 |
alg44 | algD | DR97_4400 | DR97_4402 | Alginate biosynthesis protein alg44; Required for alginate biosynthesis | Gdp-mannose 6-dehydrogenase; Catalyzes the oxidation of guanosine diphospho-D-mannose (GDP-D-mannose) to GDP-D-mannuronic acid, a precursor for alginate polymerization. The alginate layer causes a mucoid phenotype and provides a protective barrier against host immune defenses and antibiotics | 0.995 |
alg44 | algE | DR97_4400 | DR97_4398 | Alginate biosynthesis protein alg44; Required for alginate biosynthesis | Alginate production outer membrane protein; Has non-porin-like, channel-forming properties and probably functions as an alginate permeability pore | 0.997 |
alg44 | algG | DR97_4400 | DR97_4397 | Alginate biosynthesis protein alg44; Required for alginate biosynthesis | Poly(beta-d-mannuronate) c5 epimerase; Catalyzes the epimerization of beta-D-mannuronate to alpha-L- guluronate during the synthesis of the linear polysaccharide alginate . In addition, is part of a periplasmic protein complex that protects alginate from degradation by AlgL by channeling the newly formed alginate polymer through a scaffold that transfers the alginate polymer through the periplasmic space to the outer membrane secretin AlgE | 0.999 |
alg44 | algL | DR97_4400 | DR97_4395 | Alginate biosynthesis protein alg44; Required for alginate biosynthesis | Poly(beta-d-mannuronate) lyase; Catalyzes the depolymerization of alginate by cleaving the beta-1,4 glycosidic bond between two adjacent sugar residues via a beta-elimination mechanism May serve to degrade mislocalized alginate that is trapped in the periplasmic space. Acts preferentially on non-acetylated alginate or its precursor mannuronan. Is able to catalyze cleavage adjacent to either mannuronate or guluronate residues in alginate. Exhaustive digestion of alginate by AlgL generates dimeric and trimeric products . In addition to its enzymatic function, AlgL appears to be required [...] | 0.993 |
alg44 | algX | DR97_4400 | DR97_4396 | Alginate biosynthesis protein alg44; Required for alginate biosynthesis | Putative alginate biosynthesis protein algx; Plays two roles in the biosynthesis of the exopolysaccharide alginate: protects alginate from degradation as the polymer traverses the periplasm, and also plays a role in its O-acetylation. Acetylation of alginate causes the cells in the biofilm to adhere better to lung epithelium, form microcolonies, and resist the effects of the host immune system and/or antibiotics. Displays a low acetylesterase activity in vitro using a pseudosubstrate, 3-carboxyumbelliferyl acetate. Probably has acetyltransferase activity in vivo | 0.996 |
alg8 | alg44 | DR97_4401 | DR97_4400 | Glycosyltransferase like 2 family protein; Processive enzyme that polymerizes GDP-mannuronic acid | Alginate biosynthesis protein alg44; Required for alginate biosynthesis | 0.999 |
alg8 | algA | DR97_4401 | DR97_4391 | Glycosyltransferase like 2 family protein; Processive enzyme that polymerizes GDP-mannuronic acid | Mannose-1-phosphate guanylyltransferase / mannose-6-phosphate isomerase; Produces a precursor for alginate polymerization. The alginate layer provides a protective barrier against host immune defenses and antibiotics | 0.894 |
alg8 | algD | DR97_4401 | DR97_4402 | Glycosyltransferase like 2 family protein; Processive enzyme that polymerizes GDP-mannuronic acid | Gdp-mannose 6-dehydrogenase; Catalyzes the oxidation of guanosine diphospho-D-mannose (GDP-D-mannose) to GDP-D-mannuronic acid, a precursor for alginate polymerization. The alginate layer causes a mucoid phenotype and provides a protective barrier against host immune defenses and antibiotics | 0.997 |
alg8 | algE | DR97_4401 | DR97_4398 | Glycosyltransferase like 2 family protein; Processive enzyme that polymerizes GDP-mannuronic acid | Alginate production outer membrane protein; Has non-porin-like, channel-forming properties and probably functions as an alginate permeability pore | 0.994 |
alg8 | algG | DR97_4401 | DR97_4397 | Glycosyltransferase like 2 family protein; Processive enzyme that polymerizes GDP-mannuronic acid | Poly(beta-d-mannuronate) c5 epimerase; Catalyzes the epimerization of beta-D-mannuronate to alpha-L- guluronate during the synthesis of the linear polysaccharide alginate . In addition, is part of a periplasmic protein complex that protects alginate from degradation by AlgL by channeling the newly formed alginate polymer through a scaffold that transfers the alginate polymer through the periplasmic space to the outer membrane secretin AlgE | 0.999 |
alg8 | algL | DR97_4401 | DR97_4395 | Glycosyltransferase like 2 family protein; Processive enzyme that polymerizes GDP-mannuronic acid | Poly(beta-d-mannuronate) lyase; Catalyzes the depolymerization of alginate by cleaving the beta-1,4 glycosidic bond between two adjacent sugar residues via a beta-elimination mechanism May serve to degrade mislocalized alginate that is trapped in the periplasmic space. Acts preferentially on non-acetylated alginate or its precursor mannuronan. Is able to catalyze cleavage adjacent to either mannuronate or guluronate residues in alginate. Exhaustive digestion of alginate by AlgL generates dimeric and trimeric products . In addition to its enzymatic function, AlgL appears to be required [...] | 0.988 |
alg8 | algX | DR97_4401 | DR97_4396 | Glycosyltransferase like 2 family protein; Processive enzyme that polymerizes GDP-mannuronic acid | Putative alginate biosynthesis protein algx; Plays two roles in the biosynthesis of the exopolysaccharide alginate: protects alginate from degradation as the polymer traverses the periplasm, and also plays a role in its O-acetylation. Acetylation of alginate causes the cells in the biofilm to adhere better to lung epithelium, form microcolonies, and resist the effects of the host immune system and/or antibiotics. Displays a low acetylesterase activity in vitro using a pseudosubstrate, 3-carboxyumbelliferyl acetate. Probably has acetyltransferase activity in vivo | 0.988 |
algA | alg44 | DR97_4391 | DR97_4400 | Mannose-1-phosphate guanylyltransferase / mannose-6-phosphate isomerase; Produces a precursor for alginate polymerization. The alginate layer provides a protective barrier against host immune defenses and antibiotics | Alginate biosynthesis protein alg44; Required for alginate biosynthesis | 0.891 |
algA | alg8 | DR97_4391 | DR97_4401 | Mannose-1-phosphate guanylyltransferase / mannose-6-phosphate isomerase; Produces a precursor for alginate polymerization. The alginate layer provides a protective barrier against host immune defenses and antibiotics | Glycosyltransferase like 2 family protein; Processive enzyme that polymerizes GDP-mannuronic acid | 0.894 |
algA | algD | DR97_4391 | DR97_4402 | Mannose-1-phosphate guanylyltransferase / mannose-6-phosphate isomerase; Produces a precursor for alginate polymerization. The alginate layer provides a protective barrier against host immune defenses and antibiotics | Gdp-mannose 6-dehydrogenase; Catalyzes the oxidation of guanosine diphospho-D-mannose (GDP-D-mannose) to GDP-D-mannuronic acid, a precursor for alginate polymerization. The alginate layer causes a mucoid phenotype and provides a protective barrier against host immune defenses and antibiotics | 0.995 |
algA | algE | DR97_4391 | DR97_4398 | Mannose-1-phosphate guanylyltransferase / mannose-6-phosphate isomerase; Produces a precursor for alginate polymerization. The alginate layer provides a protective barrier against host immune defenses and antibiotics | Alginate production outer membrane protein; Has non-porin-like, channel-forming properties and probably functions as an alginate permeability pore | 0.894 |
algA | algG | DR97_4391 | DR97_4397 | Mannose-1-phosphate guanylyltransferase / mannose-6-phosphate isomerase; Produces a precursor for alginate polymerization. The alginate layer provides a protective barrier against host immune defenses and antibiotics | Poly(beta-d-mannuronate) c5 epimerase; Catalyzes the epimerization of beta-D-mannuronate to alpha-L- guluronate during the synthesis of the linear polysaccharide alginate . In addition, is part of a periplasmic protein complex that protects alginate from degradation by AlgL by channeling the newly formed alginate polymer through a scaffold that transfers the alginate polymer through the periplasmic space to the outer membrane secretin AlgE | 0.910 |
algA | algL | DR97_4391 | DR97_4395 | Mannose-1-phosphate guanylyltransferase / mannose-6-phosphate isomerase; Produces a precursor for alginate polymerization. The alginate layer provides a protective barrier against host immune defenses and antibiotics | Poly(beta-d-mannuronate) lyase; Catalyzes the depolymerization of alginate by cleaving the beta-1,4 glycosidic bond between two adjacent sugar residues via a beta-elimination mechanism May serve to degrade mislocalized alginate that is trapped in the periplasmic space. Acts preferentially on non-acetylated alginate or its precursor mannuronan. Is able to catalyze cleavage adjacent to either mannuronate or guluronate residues in alginate. Exhaustive digestion of alginate by AlgL generates dimeric and trimeric products . In addition to its enzymatic function, AlgL appears to be required [...] | 0.908 |