STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
amiCNegatively regulates the expression of the aliphatic amidase operon. AmiC functions by inhibiting the action of AmiR at the protein level. It exhibits protein kinase activity (385 aa)    
Predicted Functional Partners:
amiR
Positive controlling element of AmiE, the gene for aliphatic amidase. Acts as a transcriptional antitermination factor. It is thought to allow RNA polymerase read through a rho-independent transcription terminator between the AmiE promoter and gene
 
 0.999
amiE
Catalyzes the hydrolysis of short-chain aliphatic amides to their corresponding organic acids with release of ammonia. Enables the organism to use acetamide as both carbon and nitrogen source
 
  
 0.980
AmiB
Unlikely to encode a regulatory protein. Has ATPase activity. AmiB and AmiS may act jointly into a two component ABC transporter system
  
 
 0.944
DR97_2264
annotation not available
     
 0.934
BraD
Belongs to the binding-protein-dependent transport system permease family
 
 
 0.923
braE
Component of the high affinity leucine, isoleucine, valine, transport system (LIV-I), which is operative without Na(+) and is specific for alanine and threonine, in addition to branched-chain amino acids
  
 
 0.923
braD
Component of the high affinity leucine, isoleucine, valine, transport system (LIV-I), which is operative without Na(+) and is specific for alanine and threonine, in addition to branched-chain amino acids
 
 
 0.879
urtB
Belongs to the binding-protein-dependent transport system permease family
 
  
 0.868
amiS
Possible transporter that might be responsible for the adsorption of amidase substrates or release of their hydrolysis products. AmiB and AmiS may act jointly in to a two component ABC transporter system
     
 0.866
DR97_5028
annotation not available
      
 0.857
Your Current Organism:
Pseudomonas aeruginosa
NCBI taxonomy Id: 287
Other names: ATCC 10145, ATCC 10145-U, Bacillus aeruginosus, Bacillus pyocyaneus, Bacterium aeruginosum, Bacterium pyocyaneum, CCEB 481, CCUG 28447, CCUG 29297, CCUG 551, CFBP 2466, CIP 100720, DSM 50071, IBCS 277, IFO 12689, JCM 5962, Micrococcus pyocyaneus, NBRC 12689, NCCB 76039, NCIB 8295, NCIMB 8295, NCTC 10332, NRRL B-771, P. aeruginosa, Pseudomonas polycolor, Pseudomonas pyocyanea, Pseudomonas sp. RV3, RH 815, VKM B-588, bacterium ASFP-37, bacterium ASFP-38, bacterium ASFP-45, bacterium ASFP-46, bacterium ASFP-48
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