STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DR97_5002Uric acid transporter UacT; pbuX: xanthine permease family protein (509 aa)    
Predicted Functional Partners:
DR97_3099
Hydroxydechloroatrazine ethylaminohydrolase; Specifically deaminates 8-Oxoguanine (8-oxoG) to uric acid. 8-oxoG is formed via the oxidation of guanine within DNA by reactive oxygen species and leads, if uncorrected, to the incorporation of 8- oxoG:A mismatches and eventually to G:C to T:A transversions
 
    0.636
gcl
Tartronate-semialdehyde synthase; Belongs to the TPP enzyme family
 
   
 0.632
DR97_3444
annotation not available
 
  
 0.533
guaA
Bifunctional gmp synthase/glutamine amidotransferase protein; Catalyzes the synthesis of GMP from XMP
  
  
 0.507
guaB
Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth
  
  
 0.497
DR97_503
annotation not available
 
  
 0.487
uraH
Putative transthyretin family protein; Catalyzes the hydrolysis of 5-hydroxyisourate (HIU) to 2-oxo- 4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU)
 
  
 0.480
Gda1
Guanine deaminase; Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia
 
    0.470
pyrB
Aspartate carbamoyltransferase catalytic subunit; Asp_carb_tr: aspartate carbamoyltransferase; Belongs to the ATCase/OTCase family
  
  
 0.467
GuaD
Guanine deaminase; Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia
 
    0.455
Your Current Organism:
Pseudomonas aeruginosa
NCBI taxonomy Id: 287
Other names: ATCC 10145, ATCC 10145-U, Bacillus aeruginosus, Bacillus pyocyaneus, Bacterium aeruginosum, Bacterium pyocyaneum, CCEB 481, CCUG 28447, CCUG 29297, CCUG 551, CFBP 2466, CIP 100720, DSM 50071, IBCS 277, IFO 12689, JCM 5962, Micrococcus pyocyaneus, NBRC 12689, NCCB 76039, NCIB 8295, NCIMB 8295, NCTC 10332, NRRL B-771, P. aeruginosa, Pseudomonas polycolor, Pseudomonas pyocyanea, Pseudomonas sp. RV3, RH 815, VKM B-588, bacterium ASFP-37, bacterium ASFP-38, bacterium ASFP-45, bacterium ASFP-46, bacterium ASFP-48
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