node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SFN33686.1 | SFN42493.1 | SAMN05660413_00570 | SAMN05660413_01003 | Cystathionine beta-synthase. | Homoserine dehydrogenase. | 0.885 |
SFN33686.1 | SFN42615.1 | SAMN05660413_00570 | SAMN05660413_01011 | Cystathionine beta-synthase. | Threonine dehydratase. | 0.705 |
SFN33686.1 | SFN45942.1 | SAMN05660413_00570 | SAMN05660413_01142 | Cystathionine beta-synthase. | Serine O-acetyltransferase. | 0.972 |
SFN33686.1 | SFN59033.1 | SAMN05660413_00570 | SAMN05660413_01755 | Cystathionine beta-synthase. | L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family. | 0.774 |
SFN33686.1 | SFN74344.1 | SAMN05660413_00570 | SAMN05660413_02394 | Cystathionine beta-synthase. | Aspartate kinase. | 0.765 |
SFN33686.1 | SFN78707.1 | SAMN05660413_00570 | SAMN05660413_02568 | Cystathionine beta-synthase. | D-3-phosphoglycerate dehydrogenase; Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L- serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | 0.841 |
SFN33686.1 | glyA | SAMN05660413_00570 | SAMN05660413_03295 | Cystathionine beta-synthase. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.812 |
SFN33686.1 | ilvA | SAMN05660413_00570 | SAMN05660413_01777 | Cystathionine beta-synthase. | L-threonine ammonia-lyase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.784 |
SFN33686.1 | thrB | SAMN05660413_00570 | SAMN05660413_02395 | Cystathionine beta-synthase. | Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. | 0.792 |
SFN33686.1 | trpA | SAMN05660413_00570 | SAMN05660413_02658 | Cystathionine beta-synthase. | Tryptophan synthase, alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.792 |
SFN42493.1 | SFN33686.1 | SAMN05660413_01003 | SAMN05660413_00570 | Homoserine dehydrogenase. | Cystathionine beta-synthase. | 0.885 |
SFN42493.1 | SFN42615.1 | SAMN05660413_01003 | SAMN05660413_01011 | Homoserine dehydrogenase. | Threonine dehydratase. | 0.964 |
SFN42493.1 | SFN45942.1 | SAMN05660413_01003 | SAMN05660413_01142 | Homoserine dehydrogenase. | Serine O-acetyltransferase. | 0.925 |
SFN42493.1 | SFN59033.1 | SAMN05660413_01003 | SAMN05660413_01755 | Homoserine dehydrogenase. | L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family. | 0.921 |
SFN42493.1 | SFN74344.1 | SAMN05660413_01003 | SAMN05660413_02394 | Homoserine dehydrogenase. | Aspartate kinase. | 0.997 |
SFN42493.1 | SFN78707.1 | SAMN05660413_01003 | SAMN05660413_02568 | Homoserine dehydrogenase. | D-3-phosphoglycerate dehydrogenase; Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L- serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | 0.986 |
SFN42493.1 | glyA | SAMN05660413_01003 | SAMN05660413_03295 | Homoserine dehydrogenase. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.950 |
SFN42493.1 | ilvA | SAMN05660413_01003 | SAMN05660413_01777 | Homoserine dehydrogenase. | L-threonine ammonia-lyase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.964 |
SFN42493.1 | thrB | SAMN05660413_01003 | SAMN05660413_02395 | Homoserine dehydrogenase. | Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. | 0.998 |
SFN42493.1 | trpA | SAMN05660413_01003 | SAMN05660413_02658 | Homoserine dehydrogenase. | Tryptophan synthase, alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.948 |