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The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pcsk5Proprotein convertase subtilisin/kexin type 5b; Belongs to the peptidase S8 family. (1145 aa)    
Predicted Functional Partners:
mbtps1
Membrane-bound transcription factor peptidase, site 1.
      
 0.671
rxfp2
Relaxin family peptide receptor 2a.
   
 0.541
lgr4
Leucine-rich repeat containing G protein-coupled receptor 4.
   
 0.541
LGR5
Leucine rich repeat containing G protein-coupled receptor 5.
   
 0.541
rxfp1
Relaxin family peptide receptor 1.
   
 0.541
LOC107103699
Transforming growth factor beta; Belongs to the TGF-beta family.
    
 0.486
pcsk9
Proprotein convertase subtilisin/kexin type 9; Belongs to the peptidase S8 family.
      
 0.485
pdgfa
Platelet-derived growth factor alpha polypeptide b; Belongs to the PDGF/VEGF growth factor family.
     
 0.458
ENSCVAP00000001388
Uncharacterized protein.
     
 0.438
LOC107096024
Proopiomelanocortin.
     
 0.438
Your Current Organism:
Cyprinodon variegatus
NCBI taxonomy Id: 28743
Other names: C. variegatus, sheepshead minnow
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.