Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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LOC107094607UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (153 aa)    
Predicted Functional Partners:
ENSCVAP00000029008
Ubiquitin-conjugating enzyme E2 variant 2.
   
 0.992
traf6
TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.
    
 0.981
rnf168
E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and ubiquitinates histone H2A and H2AX, leading to amplify the RNF8-dependent H2A ubiquitination and promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recrui [...]
    
 0.976
rnf8
E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...]
   
 0.974
hltf
Helicase-like transcription factor.
    
 0.958
LOC107090723
Ubiquitin-conjugating enzyme E2 variant 1.
   
 0.957
rbx1
Ring-box 1, E3 ubiquitin protein ligase.
   
 0.955
rps27a
Ribosomal protein S27a.
   
 0.953
uba52
Ubiquitin A-52 residue ribosomal protein fusion product 1.
   
 0.950
brca1
Uncharacterized protein.
    
 0.944
Your Current Organism:
Cyprinodon variegatus
NCBI taxonomy Id: 28743
Other names: C. variegatus, sheepshead minnow
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