STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
prkraProtein kinase, interferon-inducible double stranded RNA dependent activator. (301 aa)    
Predicted Functional Partners:
dicer1
Dicer 1, ribonuclease type III; Belongs to the helicase family. Dicer subfamily.
    
 0.974
drosha
Drosha ribonuclease III.
    
 0.851
mff
Mitochondrial fission factor.
    
 0.767
mrpl44
Mitochondrial ribosomal protein L44.
    
 0.767
LOC107098936
PAZ domain-containing protein.
    
 0.743
ENSCVAP00000014567
Piwi domain-containing protein.
    
 0.743
Ago4
Argonaute RISC component 4.
    
 0.743
ENSCVAP00000014668
ArgoN domain-containing protein.
    
 0.743
LOC107084366
Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include ago2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]
    
 0.743
LOC107082980
Argonaute RISC component 1; Belongs to the argonaute family.
    
 0.743
Your Current Organism:
Cyprinodon variegatus
NCBI taxonomy Id: 28743
Other names: C. variegatus, sheepshead minnow
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