Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
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Co-expression
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[Homology]
Score
eif2ak3Eukaryotic translation initiation factor 2-alpha kinase 3. (1100 aa)    
Predicted Functional Partners:
hspa5
Heat shock protein 5; Belongs to the heat shock protein 70 family.
    
 0.999
eif2s1
Eukaryotic translation initiation factor 2, subunit 1 alpha b.
   
 0.998
LOC107082057
Nuclear factor, erythroid 2-like 2a.
   
 0.970
nfe2
Nuclear factor, erythroid 2.
   
 0.944
rpn2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the en [...]
    
   0.894
atf6
Activating transcription factor 6.
    
 0.880
dnajc3
DnaJ (Hsp40) homolog, subfamily C, member 3a.
   
 0.863
LOC107095621
DnaJ (Hsp40) homolog, subfamily C, member 3b.
   
 0.834
eif2a
Eukaryotic translation initiation factor 2A; Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl- tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner.
   
 
 0.805
atf6b
BZIP domain-containing protein.
    
 0.805
Your Current Organism:
Cyprinodon variegatus
NCBI taxonomy Id: 28743
Other names: C. variegatus, sheepshead minnow
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