STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ENSCVAP00000003372Adaptin_N domain-containing protein. (355 aa)    
Predicted Functional Partners:
gak
Cyclin G associated kinase.
   
 0.983
LOC107104443
Intersectin 2b.
    
 0.966
ENSCVAP00000031587
Uncharacterized protein.
    
 0.966
ENSCVAP00000031602
Uncharacterized protein.
    
 0.966
ap4b1
Adaptor related protein complex 4 subunit beta 1.
   
 0.919
ENSCVAP00000023658
AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.
    
 0.902
ENSCVAP00000022109
AP4E_app_platf domain-containing protein.
 
      0.899
ap2m1
AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...]
   
 0.858
ap2s1
AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.
   
 0.851
ap4m1
AP-4 complex subunit mu-1; Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways. AP-4 forms a non clathrin- associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper asym [...]
   
 0.840
Your Current Organism:
Cyprinodon variegatus
NCBI taxonomy Id: 28743
Other names: C. variegatus, sheepshead minnow
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.