STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
herc4HECT and RLD domain containing E3 ubiquitin protein ligase 4. (1047 aa)    
Predicted Functional Partners:
trip12
Thyroid hormone receptor interactor 12.
   
 
0.726
LOC107088009
Ubiquitin-conjugating enzyme E2L 3b; Belongs to the ubiquitin-conjugating enzyme family.
   
 0.670
LOC107101750
UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.
    
 0.633
ifih1
Interferon induced with helicase C domain 1.
   
 
 0.574
pde6d
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta; Promotes the release of prenylated target proteins from cellular membranes. Modulates the activity of prenylated or palmitoylated Ras family members by regulating their subcellular location. Required for normal ciliary targeting of farnesylated target proteins, such as INPP5E. Modulates the subcellular location of target proteins by acting as a GTP specific dissociation inhibitor (GDI). Increases the affinity of ARL3 for GTP by several orders of magnitude. Stabilizes ARL3-GTP by decreasing the nucleotide [...]
      
 0.516
dhx58
DEXH (Asp-Glu-X-His) box polypeptide 58.
   
 
 0.501
LOC107096288
Proteasome 26S subunit, non-ATPase 4b.
    
 
 0.493
LOC107102270
Whirlin b.
      
 0.493
LOC107101111
Proteasome 26S subunit, non-ATPase 4a.
    
 
 0.493
whrn
Whirlin a.
      
 0.493
Your Current Organism:
Cyprinodon variegatus
NCBI taxonomy Id: 28743
Other names: C. variegatus, sheepshead minnow
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.