arl2 protein (Cyprinodon variegatus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

arl2

ADP-ribosylation factor-like 2; Belongs to the small GTPase superfamily. Arf family. (184 aa)

Predicted Functional Partners:

arl2bp

0.984

pde6d

0.967

tbcd

0.963

LOC107084158

0.956

UNC119

0.915

unc119b

0.717

LOC107087981

0.717

tbcb

0.696

tbce

0.687

rab23

0.672

Your Current Organism:

Cyprinodon variegatus

NCBI taxonomy Id: 28743
Other names: C. variegatus, sheepshead minnow

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC107084158	arl2	ENSCVAP00000027144	ENSCVAP00000006840	GMP_PDE_delta domain-containing protein.	ADP-ribosylation factor-like 2; Belongs to the small GTPase superfamily. Arf family.	0.956
LOC107084158	pde6d	ENSCVAP00000027144	ENSCVAP00000010766	GMP_PDE_delta domain-containing protein.	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta; Promotes the release of prenylated target proteins from cellular membranes. Modulates the activity of prenylated or palmitoylated Ras family members by regulating their subcellular location. Required for normal ciliary targeting of farnesylated target proteins, such as INPP5E. Modulates the subcellular location of target proteins by acting as a GTP specific dissociation inhibitor (GDI). Increases the affinity of ARL3 for GTP by several orders of magnitude. Stabilizes ARL3-GTP by decreasing the nucleotide [...]	0.645
LOC107084158	rab23	ENSCVAP00000027144	ENSCVAP00000017410	GMP_PDE_delta domain-containing protein.	RAB23, member RAS oncogene family.	0.405
LOC107087981	arl2	ENSCVAP00000029550	ENSCVAP00000006840	GMP_PDE_delta domain-containing protein.	ADP-ribosylation factor-like 2; Belongs to the small GTPase superfamily. Arf family.	0.717
LOC107087981	pde6d	ENSCVAP00000029550	ENSCVAP00000010766	GMP_PDE_delta domain-containing protein.	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta; Promotes the release of prenylated target proteins from cellular membranes. Modulates the activity of prenylated or palmitoylated Ras family members by regulating their subcellular location. Required for normal ciliary targeting of farnesylated target proteins, such as INPP5E. Modulates the subcellular location of target proteins by acting as a GTP specific dissociation inhibitor (GDI). Increases the affinity of ARL3 for GTP by several orders of magnitude. Stabilizes ARL3-GTP by decreasing the nucleotide [...]	0.547
UNC119	arl2	ENSCVAP00000008373	ENSCVAP00000006840	Unc-119 lipid binding chaperone.	ADP-ribosylation factor-like 2; Belongs to the small GTPase superfamily. Arf family.	0.915
UNC119	pde6d	ENSCVAP00000008373	ENSCVAP00000010766	Unc-119 lipid binding chaperone.	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta; Promotes the release of prenylated target proteins from cellular membranes. Modulates the activity of prenylated or palmitoylated Ras family members by regulating their subcellular location. Required for normal ciliary targeting of farnesylated target proteins, such as INPP5E. Modulates the subcellular location of target proteins by acting as a GTP specific dissociation inhibitor (GDI). Increases the affinity of ARL3 for GTP by several orders of magnitude. Stabilizes ARL3-GTP by decreasing the nucleotide [...]	0.649
arl2	LOC107084158	ENSCVAP00000006840	ENSCVAP00000027144	ADP-ribosylation factor-like 2; Belongs to the small GTPase superfamily. Arf family.	GMP_PDE_delta domain-containing protein.	0.956
arl2	LOC107087981	ENSCVAP00000006840	ENSCVAP00000029550	ADP-ribosylation factor-like 2; Belongs to the small GTPase superfamily. Arf family.	GMP_PDE_delta domain-containing protein.	0.717
arl2	UNC119	ENSCVAP00000006840	ENSCVAP00000008373	ADP-ribosylation factor-like 2; Belongs to the small GTPase superfamily. Arf family.	Unc-119 lipid binding chaperone.	0.915
arl2	arl2bp	ENSCVAP00000006840	ENSCVAP00000009168	ADP-ribosylation factor-like 2; Belongs to the small GTPase superfamily. Arf family.	ADP-ribosylation factor-like 2 binding protein.	0.984
arl2	pde6d	ENSCVAP00000006840	ENSCVAP00000010766	ADP-ribosylation factor-like 2; Belongs to the small GTPase superfamily. Arf family.	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta; Promotes the release of prenylated target proteins from cellular membranes. Modulates the activity of prenylated or palmitoylated Ras family members by regulating their subcellular location. Required for normal ciliary targeting of farnesylated target proteins, such as INPP5E. Modulates the subcellular location of target proteins by acting as a GTP specific dissociation inhibitor (GDI). Increases the affinity of ARL3 for GTP by several orders of magnitude. Stabilizes ARL3-GTP by decreasing the nucleotide [...]	0.967
arl2	rab23	ENSCVAP00000006840	ENSCVAP00000017410	ADP-ribosylation factor-like 2; Belongs to the small GTPase superfamily. Arf family.	RAB23, member RAS oncogene family.	0.672
arl2	tbcb	ENSCVAP00000006840	ENSCVAP00000003811	ADP-ribosylation factor-like 2; Belongs to the small GTPase superfamily. Arf family.	Tubulin folding cofactor B.	0.696
arl2	tbcd	ENSCVAP00000006840	ENSCVAP00000024654	ADP-ribosylation factor-like 2; Belongs to the small GTPase superfamily. Arf family.	Tubulin folding cofactor D.	0.963
arl2	tbce	ENSCVAP00000006840	ENSCVAP00000015855	ADP-ribosylation factor-like 2; Belongs to the small GTPase superfamily. Arf family.	Tubulin folding cofactor E.	0.687
arl2	unc119b	ENSCVAP00000006840	ENSCVAP00000024801	ADP-ribosylation factor-like 2; Belongs to the small GTPase superfamily. Arf family.	Unc-119 homolog 1.	0.717
arl2bp	arl2	ENSCVAP00000009168	ENSCVAP00000006840	ADP-ribosylation factor-like 2 binding protein.	ADP-ribosylation factor-like 2; Belongs to the small GTPase superfamily. Arf family.	0.984
pde6d	LOC107084158	ENSCVAP00000010766	ENSCVAP00000027144	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta; Promotes the release of prenylated target proteins from cellular membranes. Modulates the activity of prenylated or palmitoylated Ras family members by regulating their subcellular location. Required for normal ciliary targeting of farnesylated target proteins, such as INPP5E. Modulates the subcellular location of target proteins by acting as a GTP specific dissociation inhibitor (GDI). Increases the affinity of ARL3 for GTP by several orders of magnitude. Stabilizes ARL3-GTP by decreasing the nucleotide [...]	GMP_PDE_delta domain-containing protein.	0.645
pde6d	LOC107087981	ENSCVAP00000010766	ENSCVAP00000029550	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta; Promotes the release of prenylated target proteins from cellular membranes. Modulates the activity of prenylated or palmitoylated Ras family members by regulating their subcellular location. Required for normal ciliary targeting of farnesylated target proteins, such as INPP5E. Modulates the subcellular location of target proteins by acting as a GTP specific dissociation inhibitor (GDI). Increases the affinity of ARL3 for GTP by several orders of magnitude. Stabilizes ARL3-GTP by decreasing the nucleotide [...]	GMP_PDE_delta domain-containing protein.	0.547