STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
rab27aRAB27A, member RAS oncogene family. (220 aa)    
Predicted Functional Partners:
LOC107081031
Melanophilin a.
    
 
 0.750
LOC107103394
Rab proteins geranylgeranyltransferase component A; Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane.
    
 0.719
cd63
Tetraspanin.
     
 0.681
madd
MAP-kinase activating death domain.
     
 0.681
rabggta
Rab geranylgeranyltransferase subunit alpha.
     
 0.664
hps3
HPS3 biogenesis of lysosomal organelles complex 2 subunit 1.
      
 0.643
hps5
Hermansky-Pudlak syndrome 5 protein homolog; May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules.
      
 0.643
snap25
Synaptosomal-associated protein; Belongs to the SNAP-25 family.
      
 0.631
hps4
HPS4 biogenesis of lysosomal organelles complex 3 subunit 2.
      
 0.625
ap3b1
AP-3 complex subunit beta; Belongs to the adaptor complexes large subunit family.
      
 0.625
Your Current Organism:
Cyprinodon variegatus
NCBI taxonomy Id: 28743
Other names: C. variegatus, sheepshead minnow
Server load: low (26%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.