STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TrispH2_004380Werner syndrome ATP-dependent helicase-like protein. (1097 aa)    
Predicted Functional Partners:
TrispH2_011604
Fanconi anemia group M protein.
   
 0.999
TrispH2_011682
CST complex subunit STN1.
   
 0.999
TrispH2_010388
Replication protein A 32 kDa subunit.
   
 0.999
TrispH2_009817
Serine/threonine-protein kinase ATR; Belongs to the PI3/PI4-kinase family.
   
 0.999
TrispH2_008087
DNA repair protein RAD52-like protein.
   
 0.999
TrispH2_007354
Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.
  
 0.999
TrispH2_004783
Replication protein A 14 kDa subunit.
    
 0.999
TrispH2_003244
Exonuclease 1.
  
 0.999
TrispH2_001266
DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.
  
 0.999
TrispH2_002012
Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.
    
 0.999
Your Current Organism:
Trichoplax sp. H2
NCBI taxonomy Id: 287889
Other names: T. sp. H2
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