STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TrispH2_000621Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex. (496 aa)    
Predicted Functional Partners:
TrispH2_008984
2-oxoisovalerate dehydrogenase subunit beta, mitochondrial.
 
 0.994
TrispH2_002057
2-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).
 
 0.991
TrispH2_001167
Dihydrolipoyl dehydrogenase.
 
 0.991
TrispH2_000052
Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.
 
 0.961
TrispH2_006670
2-oxoglutarate dehydrogenase, mitochondrial.
 
 0.950
TrispH2_004032
Putative 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial.
 
 0.946
TrispH2_004805
Citrate synthase; Belongs to the citrate synthase family.
  
 0.937
TrispH2_003613
Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits.
  
 0.918
TrispH2_007543
Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial.
   
 
 0.895
TrispH2_005082
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial; Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
  
 0.875
Your Current Organism:
Trichoplax sp. H2
NCBI taxonomy Id: 287889
Other names: T. sp. H2
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