STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Esi_0339_0028GTP cyclohydrolase I. (256 aa)    
Predicted Functional Partners:
Esi_0069_0033
Pterin-binding domain-containing protein.
  
 
 0.978
Esi_0168_0065
Uncharacterized protein.
   
   0.970
Esi_0082_0052
Uncharacterized protein.
    
   0.907
Esi_0357_0003
Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family.
  
 
 0.883
Esi_0036_0086
6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.
    
 0.777
Esi_0169_0021
Nudix hydrolase domain-containing protein.
  
 
 0.746
Esi_0018_0066
MutT-like protein.
  
 
 0.746
Esi_0111_0024
ADP-ribose pyrophosphatase; Belongs to the Nudix hydrolase family.
  
 
 0.746
Esi_0134_0091
Coronin; Belongs to the WD repeat coronin family.
    
 0.744
Esi_0008_0202
WD_REPEATS_REGION domain-containing protein.
    
 0.744
Your Current Organism:
Ectocarpus siliculosus
NCBI taxonomy Id: 2880
Other names: E. siliculosus
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.