STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Esi_0137_0065Ciliary dynein heavy chain, putative. (2821 aa)    
Predicted Functional Partners:
D1LIC
Dynein light intermediate chain; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes.
    
 0.710
D2LIC
D2LIC, cytoplasmic dynein 2 light intermediate chain.
    
 0.707
TUA
Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.
    
 0.699
TUA-2
Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.
    
 0.699
Esi_0081_0110
Uncharacterized protein.
    
 0.692
Esi_0446_0012
Lissencephaly-1 homolog; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes. Belongs to the WD repeat LIS1/nudF family.
    
 0.691
Esi_0356_0012
Uncharacterized protein.
    
 0.671
Esi_0308_0014
Robl_LC7 domain-containing protein.
    
 0.667
DLC7a
Dynein light chain roadblock.
    
 0.667
Esi_0060_0081
Robl_LC7 domain-containing protein.
    
 0.667
Your Current Organism:
Ectocarpus siliculosus
NCBI taxonomy Id: 2880
Other names: E. siliculosus
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.