DmpE protein (Beggiatoa leptomitoformis) - STRING interaction network

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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Score

DmpE

2-oxopent-4-enoate hydratase. (260 aa)

Predicted Functional Partners:

DmpG

0.991

AL038_01295

0.965

DmpH

0.960

AL038_01315

0.938

AL038_01305

0.799

AL038_01310

0.795

AL038_01320

0.705

AL038_01280

0.637

AL038_01330

0.599

AL038_01325

0.592

Your Current Organism:

Beggiatoa leptomitoformis

NCBI taxonomy Id: 288004
Other names: B. leptomitoformis, Beggiatoa leptomitiformis, Beggiatoa leptomitoformis Dubinina et al. 2017, Beggiatoa sp. D-402, DSM 14946, UNIQEM U 779, strain D-402

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AL038_01280	AL038_01295	AL038_01280	AL038_01295	Tautomerase; Belongs to the 4-oxalocrotonate tautomerase family.	Acetaldehyde dehydrogenase; Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD(+) and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds.	0.773
AL038_01280	AL038_01305	AL038_01280	AL038_01305	Tautomerase; Belongs to the 4-oxalocrotonate tautomerase family.	2-hydroxymuconic semialdehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.	0.948
AL038_01280	AL038_01310	AL038_01280	AL038_01310	Tautomerase; Belongs to the 4-oxalocrotonate tautomerase family.	Cobalamin adenosyltransferase.	0.609
AL038_01280	AL038_01315	AL038_01280	AL038_01315	Tautomerase; Belongs to the 4-oxalocrotonate tautomerase family.	Catechol 2,3-dioxygenase.	0.983
AL038_01280	AL038_01320	AL038_01280	AL038_01320	Tautomerase; Belongs to the 4-oxalocrotonate tautomerase family.	Ferredoxin.	0.824
AL038_01280	AL038_01325	AL038_01280	AL038_01325	Tautomerase; Belongs to the 4-oxalocrotonate tautomerase family.	Phenol hydroxylase.	0.533
AL038_01280	AL038_01330	AL038_01280	AL038_01330	Tautomerase; Belongs to the 4-oxalocrotonate tautomerase family.	Phenol hydroxylase.	0.740
AL038_01280	DmpE	AL038_01280	AL038_01300	Tautomerase; Belongs to the 4-oxalocrotonate tautomerase family.	2-oxopent-4-enoate hydratase.	0.637
AL038_01280	DmpG	AL038_01280	AL038_01290	Tautomerase; Belongs to the 4-oxalocrotonate tautomerase family.	4-hydroxy-2-oxovalerate aldolase; Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta- cleavage pathway for the degradation of aromatic compounds. Belongs to the 4-hydroxy-2-oxovalerate aldolase family.	0.766
AL038_01280	DmpH	AL038_01280	AL038_01285	Tautomerase; Belongs to the 4-oxalocrotonate tautomerase family.	4-oxalocrotonate decarboxylase.	0.980
AL038_01295	AL038_01280	AL038_01295	AL038_01280	Acetaldehyde dehydrogenase; Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD(+) and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds.	Tautomerase; Belongs to the 4-oxalocrotonate tautomerase family.	0.773
AL038_01295	AL038_01305	AL038_01295	AL038_01305	Acetaldehyde dehydrogenase; Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD(+) and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds.	2-hydroxymuconic semialdehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.	0.586
AL038_01295	AL038_01310	AL038_01295	AL038_01310	Acetaldehyde dehydrogenase; Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD(+) and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds.	Cobalamin adenosyltransferase.	0.646
AL038_01295	AL038_01315	AL038_01295	AL038_01315	Acetaldehyde dehydrogenase; Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD(+) and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds.	Catechol 2,3-dioxygenase.	0.880
AL038_01295	AL038_01320	AL038_01295	AL038_01320	Acetaldehyde dehydrogenase; Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD(+) and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds.	Ferredoxin.	0.674
AL038_01295	AL038_01325	AL038_01295	AL038_01325	Acetaldehyde dehydrogenase; Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD(+) and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds.	Phenol hydroxylase.	0.572
AL038_01295	AL038_01330	AL038_01295	AL038_01330	Acetaldehyde dehydrogenase; Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD(+) and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds.	Phenol hydroxylase.	0.583
AL038_01295	DmpE	AL038_01295	AL038_01300	Acetaldehyde dehydrogenase; Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD(+) and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds.	2-oxopent-4-enoate hydratase.	0.965
AL038_01295	DmpG	AL038_01295	AL038_01290	Acetaldehyde dehydrogenase; Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD(+) and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds.	4-hydroxy-2-oxovalerate aldolase; Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta- cleavage pathway for the degradation of aromatic compounds. Belongs to the 4-hydroxy-2-oxovalerate aldolase family.	0.999
AL038_01295	DmpH	AL038_01295	AL038_01285	Acetaldehyde dehydrogenase; Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD(+) and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds.	4-oxalocrotonate decarboxylase.	0.978

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Network Stats

number of nodes:

11

number of edges:

34

average node degree:

6.18

avg. local clustering coefficient:

0.636

expected number of edges:

15

PPI enrichment p-value:

2.32e-05

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005978

Glycogen biosynthetic process

3 of 8

2.35

1.83

0.00036

GO:0005975

Carbohydrate metabolic process

7 of 326

1.1

1.03

0.00029

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016758

Hexosyltransferase activity

3 of 17

2.02

1.33

0.0027

GO:0102752

1,4-alpha-glucan branching enzyme activity (using a glucosylated glycogenin as primer for glycogen synthesis)

2 of 5

2.37

0.94

0.0186

GO:0003844

1,4-alpha-glucan branching enzyme activity

2 of 5

2.37

0.94

0.0186

GO:0004553

Hydrolase activity, hydrolyzing O-glycosyl compounds

3 of 50

1.55

0.83

0.0186

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005829

Cytosol

5 of 344

0.94

0.57

0.0211

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:4821

Starch and sucrose metabolism, and Amino acid/polyamine transporter I

10 of 26

2.36

8.34

9.26e-20

CL:4825

Glycogen metabolic process, and Alpha-amylase domain

6 of 13

2.44

5.31

1.86e-11

CL:4863

Amino acid/polyamine transporter I, and Alpha amylase, catalytic domain

4 of 5

2.68

3.8

7.03e-08

CL:4827

Glycosyl hydrolase, all-beta

4 of 7

2.53

3.55

1.67e-07

CL:4841

Glycogen biosynthesis, and Carbohydrate phosphorylase

2 of 5

2.37

1.21

0.0058

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

pls00500

Starch and sucrose metabolism

7 of 27

2.19

5.23

1.99e-12

pls01110

Biosynthesis of secondary metabolites

6 of 327

1.04

0.94

0.00036

pls01100

Metabolic pathways

7 of 701

0.77

0.62

0.0014

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0031588

Nucleotide-activated protein kinase complex

2 of 6

2.3

0.94

0.0189

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0320

Glycogen biosynthesis

3 of 5

2.55

2.35

4.14e-05

KW-0119

Carbohydrate metabolism

3 of 14

2.1

1.84

0.00025

KW-0321

Glycogen metabolism

2 of 3

2.6

1.57

0.0013

KW-0328

Glycosyltransferase

4 of 69

1.54

1.47

0.00031

KW-0326

Glycosidase

3 of 36

1.69

1.35

0.0013

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00324

Amino acid permease

3 of 3

2.77

2.35

4.81e-05

PF00128

Alpha amylase, catalytic domain

3 of 10

2.25

1.82

0.00034

PF16657

Maltogenic Amylase, C-terminal domain

2 of 2

2.77

1.35

0.0035

PF02806

Alpha amylase, C-terminal all-beta domain

2 of 2

2.77

1.35

0.0035

PF02922

Carbohydrate-binding module 48 (Isoamylase N-terminal domain)

2 of 6

2.3

1.09

0.0097

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR013780

Glycosyl hydrolase, all-beta

5 of 8

2.57

4.17

1.02e-08

IPR006047

Glycosyl hydrolase, family 13, catalytic domain

5 of 12

2.39

3.86

2.44e-08

IPR017853

Glycoside hydrolase superfamily

5 of 27

2.04

2.95

5.23e-07

IPR045857

Oligo-1,6-glucosidase, domain 2

2 of 2

2.77

1.2

0.0066

IPR044143

Glycogen branching enzyme GlgB, N-terminal Early set domain

2 of 2

2.77

1.2

0.0066

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00642

Alpha-amylase domain

2 of 2

2.77

1.5

0.0019

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