AL038_10140 protein (Beggiatoa leptomitoformis)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

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[Homology]

Score

AL038_10140

DUF2760 domain-containing protein. (180 aa)

Predicted Functional Partners:

AL038_10145

0.948

AL038_05245

0.782

UbiH

0.472

AL038_11740

0.437

Your Current Organism:

Beggiatoa leptomitoformis

NCBI taxonomy Id: 288004
Other names: B. leptomitoformis, Beggiatoa leptomitiformis, Beggiatoa leptomitoformis Dubinina et al. 2017, Beggiatoa sp. D-402, DSM 14946, UNIQEM U 779, strain D-402

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AL038_05245	AL038_10140	AL038_05245	AL038_10140	Molecular chaperone DnaK.	DUF2760 domain-containing protein.	0.782
AL038_05245	AL038_11740	AL038_05245	AL038_11740	Molecular chaperone DnaK.	Uncharacterized protein.	0.418
AL038_10140	AL038_05245	AL038_10140	AL038_05245	DUF2760 domain-containing protein.	Molecular chaperone DnaK.	0.782
AL038_10140	AL038_10145	AL038_10140	AL038_10145	DUF2760 domain-containing protein.	Molecular chaperone DnaK; Belongs to the heat shock protein 70 family.	0.948
AL038_10140	AL038_11740	AL038_10140	AL038_11740	DUF2760 domain-containing protein.	Uncharacterized protein.	0.437
AL038_10140	UbiH	AL038_10140	AL038_10135	DUF2760 domain-containing protein.	2-octaprenyl-6-methoxyphenyl hydroxylase.	0.472
AL038_10145	AL038_10140	AL038_10145	AL038_10140	Molecular chaperone DnaK; Belongs to the heat shock protein 70 family.	DUF2760 domain-containing protein.	0.948
AL038_10145	AL038_11740	AL038_10145	AL038_11740	Molecular chaperone DnaK; Belongs to the heat shock protein 70 family.	Uncharacterized protein.	0.443
AL038_10145	UbiH	AL038_10145	AL038_10135	Molecular chaperone DnaK; Belongs to the heat shock protein 70 family.	2-octaprenyl-6-methoxyphenyl hydroxylase.	0.503
AL038_11740	AL038_05245	AL038_11740	AL038_05245	Uncharacterized protein.	Molecular chaperone DnaK.	0.418
AL038_11740	AL038_10140	AL038_11740	AL038_10140	Uncharacterized protein.	DUF2760 domain-containing protein.	0.437
AL038_11740	AL038_10145	AL038_11740	AL038_10145	Uncharacterized protein.	Molecular chaperone DnaK; Belongs to the heat shock protein 70 family.	0.443
UbiH	AL038_10140	AL038_10135	AL038_10140	2-octaprenyl-6-methoxyphenyl hydroxylase.	DUF2760 domain-containing protein.	0.472
UbiH	AL038_10145	AL038_10135	AL038_10145	2-octaprenyl-6-methoxyphenyl hydroxylase.	Molecular chaperone DnaK; Belongs to the heat shock protein 70 family.	0.503

Network Stats

number of nodes:

11

number of edges:

18

average node degree:

3.27

avg. local clustering coefficient:

0.898

expected number of edges:

13

PPI enrichment p-value:

0.0888

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006352

DNA-templated transcription, initiation

9 of 46

1.92

4.77

1.31e-13

GO:0050896

Response to stimulus

9 of 308

1.1

1.4

4.91e-08

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016987

Sigma factor activity

9 of 46

1.92

4.83

7.61e-14

GO:0140110

Transcription regulator activity

11 of 162

1.46

2.95

7.61e-14

GO:0003677

DNA binding

9 of 372

1.01

1.15

1.11e-06

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005737

Cytoplasm

9 of 1163

0.52

0.36

0.0138

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:5963

FecR protein, and RNA polymerase sigma-70, Bacteroidetes type

11 of 42

2.05

6.79

1.23e-19

CL:5970

FecR protein, and RNA polymerase sigma-70, Bacteroidetes type

9 of 25

2.19

6.62

1.32e-16

CL:5973

FecR protein, and RNA polymerase sigma-70, Bacteroidetes type

7 of 17

2.24

5.45

1.12e-12

CL:5974

FecR protein, and RNA polymerase sigma-70 region 4

5 of 11

2.29

3.94

9.48e-09

CL:5986

RNA polymerase sigma-70 region 4, and FecR protein

3 of 5

2.41

2.3

4.42e-05

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map02020

Two-component system

11 of 459

1.01

1.29

1.05e-09

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0000428

DNA-directed RNA polymerase complex

9 of 76

1.7

3.71

2.14e-12

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0731

Sigma factor

9 of 43

1.95

5.13

1.33e-14

KW-0238

DNA-binding

9 of 192

1.3

2.03

1.05e-09

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF04542

Sigma-70 region 2

9 of 42

1.96

5.07

3.49e-14

PF08281

Sigma-70, region 4

4 of 24

1.85

1.87

0.00011

PF04545

Sigma-70, region 4

3 of 16

1.9

1.36

0.0020

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR007627

RNA polymerase sigma-70 region 2

9 of 40

1.98

5.09

5.76e-14

IPR039425

RNA polymerase sigma-70 like

9 of 41

1.97

5.05

5.76e-14

IPR014327

RNA polymerase sigma-70, Bacteroidetes type

7 of 20

2.17

4.99

7.64e-12

IPR013325

RNA polymerase sigma factor, region 2

9 of 43

1.95

4.97

5.76e-14

IPR014284

RNA polymerase sigma-70 like domain

9 of 44

1.94

4.94

5.76e-14

(more ...)

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