node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AL038_07670 | Amt | AL038_07670 | AL038_00705 | Two-component system sensor histidine kinase NtrB. | Ammonia permease. | 0.720 |
AL038_07670 | GlnB | AL038_07670 | AL038_16375 | Two-component system sensor histidine kinase NtrB. | Transcriptional regulator; Belongs to the P(II) protein family. | 0.965 |
AL038_07670 | GlnK | AL038_07670 | AL038_08055 | Two-component system sensor histidine kinase NtrB. | Transcriptional regulator; Belongs to the P(II) protein family. | 0.665 |
AL038_07670 | GltB | AL038_07670 | AL038_03600 | Two-component system sensor histidine kinase NtrB. | Glutamate synthase large subunit. | 0.590 |
AL038_07670 | glnD | AL038_07670 | AL038_17115 | Two-component system sensor histidine kinase NtrB. | Bifunctional uridylyltransferase/uridylyl-removing enzyme; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen metabolism. | 0.516 |
AL038_17110 | glnD | AL038_17110 | AL038_17115 | Uncharacterized protein. | Bifunctional uridylyltransferase/uridylyl-removing enzyme; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen metabolism. | 0.503 |
AL038_17940 | Amt | AL038_17940 | AL038_00705 | Glutamine synthetase. | Ammonia permease. | 0.654 |
AL038_17940 | GltB | AL038_17940 | AL038_03600 | Glutamine synthetase. | Glutamate synthase large subunit. | 0.971 |
AL038_17940 | glnD | AL038_17940 | AL038_17115 | Glutamine synthetase. | Bifunctional uridylyltransferase/uridylyl-removing enzyme; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen metabolism. | 0.424 |
AL038_17940 | glnE | AL038_17940 | AL038_14305 | Glutamine synthetase. | Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory regi [...] | 0.737 |
Amt | AL038_07670 | AL038_00705 | AL038_07670 | Ammonia permease. | Two-component system sensor histidine kinase NtrB. | 0.720 |
Amt | AL038_17940 | AL038_00705 | AL038_17940 | Ammonia permease. | Glutamine synthetase. | 0.654 |
Amt | GlnB | AL038_00705 | AL038_16375 | Ammonia permease. | Transcriptional regulator; Belongs to the P(II) protein family. | 0.981 |
Amt | GlnK | AL038_00705 | AL038_08055 | Ammonia permease. | Transcriptional regulator; Belongs to the P(II) protein family. | 0.985 |
Amt | GltB | AL038_00705 | AL038_03600 | Ammonia permease. | Glutamate synthase large subunit. | 0.874 |
Amt | glnD | AL038_00705 | AL038_17115 | Ammonia permease. | Bifunctional uridylyltransferase/uridylyl-removing enzyme; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen metabolism. | 0.456 |
Amt | glnE | AL038_00705 | AL038_14305 | Ammonia permease. | Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory regi [...] | 0.442 |
GlnB | AL038_07670 | AL038_16375 | AL038_07670 | Transcriptional regulator; Belongs to the P(II) protein family. | Two-component system sensor histidine kinase NtrB. | 0.965 |
GlnB | Amt | AL038_16375 | AL038_00705 | Transcriptional regulator; Belongs to the P(II) protein family. | Ammonia permease. | 0.981 |
GlnB | GltB | AL038_16375 | AL038_03600 | Transcriptional regulator; Belongs to the P(II) protein family. | Glutamate synthase large subunit. | 0.536 |