ABY24822.1 protein (Renibacterium salmoninarum)

Nodes:

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
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Edges:

Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

ABY24822.1

Universal stress protein family. (140 aa)

Predicted Functional Partners:

ABY24305.1

0.555

ABY24823.1

0.551

ABY25018.1

0.534

ABY24796.1

0.520

ABY24120.1

0.519

ABY25257.1

0.505

ABY22974.1

0.501

hpf

0.498

ABY24370.1

0.467

ABY24138.1

0.466

Your Current Organism:

Renibacterium salmoninarum

NCBI taxonomy Id: 288705
Other names: R. salmoninarum ATCC 33209, Renibacterium salmoninarum ATCC 33209, Renibacterium salmoninarum str. ATCC 33209, Renibacterium salmoninarum strain ATCC 33209

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABY22974.1	ABY24370.1	RSal33209_1236	RSal33209_2645	Macrolide 2'-phosphotransferase, putative.	PAP2 superfamily protein.	0.620
ABY22974.1	ABY24822.1	RSal33209_1236	RSal33209_3104	Macrolide 2'-phosphotransferase, putative.	Universal stress protein family.	0.501
ABY22974.1	ABY25257.1	RSal33209_1236	RSal33209_3548	Macrolide 2'-phosphotransferase, putative.	Hypothetical protein.	0.613
ABY24120.1	ABY24822.1	RSal33209_2394	RSal33209_3104	Cation-transporting ATPase.	Universal stress protein family.	0.519
ABY24138.1	ABY24822.1	RSal33209_2412	RSal33209_3104	acetyl-CoA synthetase.	Universal stress protein family.	0.466
ABY24138.1	ABY25257.1	RSal33209_2412	RSal33209_3548	acetyl-CoA synthetase.	Hypothetical protein.	0.451
ABY24305.1	ABY24822.1	RSal33209_2580	RSal33209_3104	Hypothetical membrane spanning protein.	Universal stress protein family.	0.555
ABY24305.1	ABY25257.1	RSal33209_2580	RSal33209_3548	Hypothetical membrane spanning protein.	Hypothetical protein.	0.790
ABY24370.1	ABY22974.1	RSal33209_2645	RSal33209_1236	PAP2 superfamily protein.	Macrolide 2'-phosphotransferase, putative.	0.620
ABY24370.1	ABY24822.1	RSal33209_2645	RSal33209_3104	PAP2 superfamily protein.	Universal stress protein family.	0.467
ABY24370.1	ABY25257.1	RSal33209_2645	RSal33209_3548	PAP2 superfamily protein.	Hypothetical protein.	0.613
ABY24796.1	ABY24822.1	RSal33209_3075	RSal33209_3104	Hypothetical protein.	Universal stress protein family.	0.520
ABY24796.1	ABY25257.1	RSal33209_3075	RSal33209_3548	Hypothetical protein.	Hypothetical protein.	0.701
ABY24822.1	ABY22974.1	RSal33209_3104	RSal33209_1236	Universal stress protein family.	Macrolide 2'-phosphotransferase, putative.	0.501
ABY24822.1	ABY24120.1	RSal33209_3104	RSal33209_2394	Universal stress protein family.	Cation-transporting ATPase.	0.519
ABY24822.1	ABY24138.1	RSal33209_3104	RSal33209_2412	Universal stress protein family.	acetyl-CoA synthetase.	0.466
ABY24822.1	ABY24305.1	RSal33209_3104	RSal33209_2580	Universal stress protein family.	Hypothetical membrane spanning protein.	0.555
ABY24822.1	ABY24370.1	RSal33209_3104	RSal33209_2645	Universal stress protein family.	PAP2 superfamily protein.	0.467
ABY24822.1	ABY24796.1	RSal33209_3104	RSal33209_3075	Universal stress protein family.	Hypothetical protein.	0.520
ABY24822.1	ABY24823.1	RSal33209_3104	RSal33209_3105	Universal stress protein family.	Guanine-hypoxanthine permease.	0.551

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

26

average node degree:

4.73

avg. local clustering coefficient:

0.528

expected number of edges:

11

PPI enrichment p-value:

4.75e-05

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0008380

RNA splicing

11 of 334

1.97

6.15

9.36e-19

GO:0000398

mRNA splicing, via spliceosome

10 of 277

2.01

6.0

3.65e-17

GO:0006397

mRNA processing

11 of 387

1.9

5.72

2.30e-18

GO:0000393

Spliceosomal conformational changes to generate catalytic conformation

3 of 12

2.85

3.0

3.02e-06

GO:0000349

Generation of catalytic spliceosome for first transesterification step

2 of 6

2.97

1.85

0.00044

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000974

Prp19 complex

6 of 18

2.97

7.43

1.08e-14

GO:0005681

Spliceosomal complex

11 of 249

2.1

7.32

9.40e-21

GO:0071006

U2-type catalytic step 1 spliceosome

3 of 5

3.23

3.67

2.15e-07

GO:0005684

U2-type spliceosomal complex

4 of 56

2.3

3.25

3.73e-07

GO:0071007

U2-type catalytic step 2 spliceosome

3 of 13

2.81

3.16

1.51e-06

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:7907

mRNA Splicing

11 of 190

2.21

8.18

1.64e-21

CL:8162

Spliceosomal conformational changes to generate catalytic conformation, and mRNA Splicing - Major Pathway

6 of 42

2.61

5.83

3.89e-12

CL:8077

Beta-catenin-like protein 1, and Prp19 complex

4 of 5

3.35

5.21

3.44e-10

CL:8166

Mixed, incl. Catalytic step 1 spliceosome, and Post-spliceosomal complex

4 of 10

3.05

4.69

2.43e-09

CL:7914

Sm-like protein family complex, and mRNA Splicing

5 of 92

2.19

3.66

2.41e-08

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03040

Spliceosome

10 of 778

1.56

3.31

1.63e-13

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-72163

mRNA Splicing - Major Pathway

9 of 212

2.08

5.85

2.05e-15

MAP-72172

mRNA Splicing

9 of 243

2.02

5.55

3.40e-15

MAP-72203

Processing of Capped Intron-Containing Pre-mRNA

9 of 356

1.85

4.58

6.62e-14

MAP-8953854

Metabolism of RNA

9 of 828

1.49

2.7

8.95e-11

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0000974

Prp19 complex

5 of 15

2.97

5.66

3.01e-11

GOCC:0005684

U2-type spliceosomal complex

4 of 44

2.41

3.15

8.33e-07

GOCC:0005681

Spliceosomal complex

5 of 202

1.84

2.56

1.42e-06

GOCC:1990904

Ribonucleoprotein complex

6 of 553

1.49

1.94

2.88e-06

GOCC:0071007

U2-type catalytic step 2 spliceosome

2 of 10

2.75

1.62

0.0011

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0175

Coiled coil

8 of 4168

0.73

0.56

0.0028

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR045075

Pre-mRNA-splicing factor Syf1-like

2 of 3

3.27

1.35

0.0037

IPR003107

HAT (Half-A-TPR) repeat

2 of 9

2.8

1.1

0.0101

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00386

HAT (Half-A-TPR) repeats

2 of 9

2.8

1.46

0.0022

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