node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
acyH | guaA_2 | SAMEA3906486_01398 | SAMEA3906486_03702 | S-adenosyl-L-homocysteine hydrolase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.475 |
acyH | metE_1 | SAMEA3906486_01398 | SAMEA3906486_01536 | S-adenosyl-L-homocysteine hydrolase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase. | 0.872 |
acyH | metE_2 | SAMEA3906486_01398 | SAMEA3906486_03688 | S-adenosyl-L-homocysteine hydrolase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase. | 0.872 |
acyH | metE_3 | SAMEA3906486_01398 | SAMEA3906486_03873 | S-adenosyl-L-homocysteine hydrolase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | 5- methyltetrahydropteroyltriglutamate/homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | 0.972 |
acyH | metE_4 | SAMEA3906486_01398 | SAMEA3906486_04532 | S-adenosyl-L-homocysteine hydrolase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase. | 0.872 |
acyH | metF_1 | SAMEA3906486_01398 | SAMEA3906486_01400 | S-adenosyl-L-homocysteine hydrolase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.874 |
acyH | metH | SAMEA3906486_01398 | SAMEA3906486_01721 | S-adenosyl-L-homocysteine hydrolase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | B12-dependent methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.971 |
acyH | metK | SAMEA3906486_01398 | SAMEA3906486_01385 | S-adenosyl-L-homocysteine hydrolase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.895 |
guaA_2 | acyH | SAMEA3906486_03702 | SAMEA3906486_01398 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | S-adenosyl-L-homocysteine hydrolase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | 0.475 |
guaA_2 | metH | SAMEA3906486_03702 | SAMEA3906486_01721 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | B12-dependent methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.562 |
guaA_2 | metK | SAMEA3906486_03702 | SAMEA3906486_01385 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.849 |
metE_1 | acyH | SAMEA3906486_01536 | SAMEA3906486_01398 | 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase. | S-adenosyl-L-homocysteine hydrolase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | 0.872 |
metE_1 | metE_3 | SAMEA3906486_01536 | SAMEA3906486_03873 | 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase. | 5- methyltetrahydropteroyltriglutamate/homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | 0.768 |
metE_1 | metF_1 | SAMEA3906486_01536 | SAMEA3906486_01400 | 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase. | Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.896 |
metE_1 | metH | SAMEA3906486_01536 | SAMEA3906486_01721 | 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase. | B12-dependent methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.928 |
metE_1 | metK | SAMEA3906486_01536 | SAMEA3906486_01385 | 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase. | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.903 |
metE_1 | tyrB | SAMEA3906486_01536 | SAMEA3906486_03759 | 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase. | Aromatic amino acid aminotransferase. | 0.689 |
metE_2 | acyH | SAMEA3906486_03688 | SAMEA3906486_01398 | 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase. | S-adenosyl-L-homocysteine hydrolase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | 0.872 |
metE_2 | metF_1 | SAMEA3906486_03688 | SAMEA3906486_01400 | 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase. | Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.896 |
metE_2 | metH | SAMEA3906486_03688 | SAMEA3906486_01721 | 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase. | B12-dependent methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.928 |