STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
EJG05995.1PFAM: PHP domain; COGs: COG0613 metal-dependent phosphoesterase (PHP family); InterPro IPR003141:IPR004013; KEGG: mem:Memar_2300 phosphotransferase domain-containing protein; PFAM: PHP, C-terminal; SMART: Polymerase/histidinol phosphatase, N-terminal; SPTR: PHP C-terminal domain protein. (221 aa)    
Predicted Functional Partners:
truA
tRNA pseudouridine synthase A; Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs; Belongs to the tRNA pseudouridine synthase TruA family.
       0.945
EJG05994.1
TIGRFAM: dihydropteroate synthase-related protein; InterPro IPR000489:IPR005236; KEGG: mbn:Mboo_0215 dihydropteroate synthase-related protein; PFAM: Dihydropteroate synthase, DHPS; SPTR: Dihydropteroate synthase-related protein; TIGRFAM: Dihydropteroate synthase-related protein synthase-related protein.
       0.725
EJG05997.1
Thiamine pyrophosphate TPP-binding domain-containing protein; PFAM: Thiamine pyrophosphate enzyme, C-terminal TPP binding domain; COGs: COG1013 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductase beta subunit; InterPro IPR011766; KEGG: mpl:Mpal_2716 thiamine pyrophosphate protein domain protein TPP-binding; PFAM: Thiamine pyrophosphate enzyme, C-terminal TPP-binding; SPTR: Thiamine pyrophosphate protein domain protein TPP-binding.
    
  0.713
EJG05998.1
PFAM: domain; COGs: COG0674 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductase alpha subunit; InterPro IPR002880; KEGG: mem:Memar_2319 pyruvate flavodoxin/ferredoxin oxidoreductase domain-containing protein; PFAM: Pyruvate flavodoxin/ferredoxin oxidoreductase, N-terminal; SPTR: Pyruvate flavodoxin/ferredoxin oxidoreductase domain protein.
    
  0.713
EJG05999.1
PFAM: Pyruvate ferredoxin/flavodoxin oxidoreductase; TIGRFAM: 2-oxoacid:acceptor oxidoreductase, gamma subunit, pyruvate/2-ketoisovalerate family; COGs: COG1014 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductase gamma subunit; InterPro IPR019752:IPR011894; KEGG: mbn:Mboo_0203 pyruvate/ketoisovalerate oxidoreductase, gamma subunit; PFAM: Pyruvate/ketoisovalerate oxidoreductase; SPTR: Pyruvate/ketoisovalerate oxidoreductase, gamma subunit; TIGRFAM: 2-oxoacid:acceptor oxidoreductase, gamma subunit, pyruvate/2-ketoisovalerate.
    
  0.713
EJG06000.1
PFAM: 4Fe-4S binding domain; TIGRFAM: 2-oxoacid:acceptor oxidoreductase, delta subunit, pyruvate/2-ketoisovalerate family; COGs: COG1144 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductase delta subunit; InterPro IPR001450:IPR011898; KEGG: mem:Memar_2321 pyruvate ferredoxin/flavodoxin oxidoreductase, delta subunit; PFAM: 4Fe-4S ferredoxin, iron-sulphur binding, subgroup; SPTR: Pyruvate ferredoxin/flavodoxin oxidoreductase, delta subunit; TIGRFAM: 2-oxoacid:acceptor oxidoreductase, delta subunit, pyruvate/2-ketoisovalerate.
       0.693
ribL
Cytidyltransferase-related domain protein; Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme.
       0.488
EJG05993.1
Hypothetical protein; COGs: COG1310 metal-dependent protease of the PAD1/JAB1 superfamily; KEGG: mpl:Mpal_0311 hypothetical protein; SPTR: Putative uncharacterized protein.
       0.487
EJG06001.1
PFAM: 4Fe-4S binding domain; Domain of unknown function (DUF362); COGs: COG2006 conserved hypothetical protein; InterPro IPR007160:IPR001450; KEGG: mem:Memar_0366 hypothetical protein; PFAM: Protein of unknown function DUF362; 4Fe-4S ferredoxin, iron-sulphur binding, subgroup; SPTR: Putative uncharacterized protein.
       0.446
purL
Phosphoribosylformylglycinamidine synthase 2; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist i [...]
       0.407
Your Current Organism:
Methanofollis liminatans
NCBI taxonomy Id: 28892
Other names: M. liminatans DSM 4140, Methanofollis liminatans DSM 4140, Methanofollis liminatans GKZPZ, Methanofollis liminatans str. DSM 4140, Methanofollis liminatans strain DSM 4140, Methanogenium liminatans (DSM 4140), Methanogenium liminatans DSM 4140
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