STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
EJG06014.1Cysteate synthase; Specifically catalyzes the beta-elimination of phosphate from L-phosphoserine and the beta-addition of sulfite to the dehydroalanine intermediate to produce L-cysteate. (423 aa)    
Predicted Functional Partners:
EJG06015.1
Sulfopyruvate decarboxylase, alpha subunit; PFAM: Thiamine pyrophosphate enzyme, N-terminal TPP binding domain; Thiamine pyrophosphate enzyme, C-terminal TPP binding domain; TIGRFAM: sulfopyruvate decarboxylase, beta subunit; sulfopyruvate decarboxylase, alpha subunit; COGs: COG4032 thiamine-pyrophosphate-binding protein; InterPro IPR011766; KEGG: mem:Memar_0112 thiamine pyrophosphate binding domain-containing protein; PFAM: Thiamine pyrophosphate enzyme, C-terminal TPP-binding; SPTR: Sulfopyruvate decarboxylase subunit beta / sulfopyruvate decarboxylase subunit alpha; TIGRFAM: sulfopy [...]
 
   
 0.966
EJG07144.1
PFAM: Homoserine dehydrogenase, NAD binding domain; Homoserine dehydrogenase; COGs: COG0460 Homoserine dehydrogenase; InterPro IPR005106:IPR001342; KEGG: mpl:Mpal_1993 homoserine dehydrogenase; PFAM: Homoserine dehydrogenase, catalytic; Aspartate/homoserine dehydrogenase, NAD-binding; SPTR: Homoserine dehydrogenase.
 
 0.961
EJG06012.1
PFAM: Putative Fe-S cluster; COGs: COG2000 Fe-S protein; InterPro IPR007202; KEGG: mem:Memar_0109 Fe-S cluster domain-containing protein; PFAM: Putative Fe-S cluster; SPTR: Fe-S cluster domain protein.
 
     0.950
EJG06011.1
Cobalamin synthesis protein P47K; PFAM: CobW/HypB/UreG, nucleotide-binding domain; COGs: COG0378 Ni2+-binding GTPase involved in regulation of expression and maturation of urease and hydrogenase; InterPro IPR003593:IPR003495; KEGG: mem:Memar_0108 cobalamin synthesis protein, P47K; PFAM: Cobalamin (vitamin B12) biosynthesis CobW-like; SMART: ATPase, AAA+ type, core; SPTR: Cobalamin synthesis protein, P47K.
 
     0.947
EJG06013.1
Methanogenesis marker 16 metalloprotein; PFAM: Domain of unknown function DUF39; TIGRFAM: putative methanogenesis marker 16 metalloprotein; COGs: COG1900 conserved hypothetical protein; InterPro IPR002708:IPR001450:IPR017677; KEGG: mem:Memar_0110 hypothetical protein; PFAM: Protein of unknown function DUF39; 4Fe-4S ferredoxin, iron-sulphur binding, subgroup; SPTR: Putative uncharacterized protein; TIGRFAM: Putative methanogenesis marker 16 metalloprotein.
 
   
 0.941
EJG08253.1
PFAM: Amino acid kinase family; ACT domain; TIGRFAM: aspartate kinase, monofunctional class; aspartate kinase; COGs: COG0527 Aspartokinase; InterPro IPR001048:IPR002912:IPR005260:IPR001341; KEGG: mpl:Mpal_0401 aspartate kinase; PFAM: Aspartate/glutamate/uridylate kinase; Amino acid-binding ACT; SPTR: Aspartokinase; TIGRFAM: Aspartate kinase region; Aspartate kinase, monofunctional class; Belongs to the aspartokinase family.
  
 
 0.892
EJG06010.1
PFAM: ABC transporter; COGs: COG1136 ABC-type antimicrobial peptide transport system ATPase component; InterPro IPR003593:IPR003439; KEGG: mem:Memar_0107 ABC transporter-related protein; PFAM: ABC transporter-like; SMART: ATPase, AAA+ type, core; SPTR: ABC transporter-related protein.
       0.843
EJG06489.1
PFAM: Aconitase C-terminal domain; TIGRFAM: 3-isopropylmalate dehydratase, small subunit; COGs: COG0066 3-isopropylmalate dehydratase small subunit; InterPro IPR011827:IPR000573; KEGG: mem:Memar_0635 3-isopropylmalate dehydratase, small subunit; PFAM: Aconitase A/isopropylmalate dehydratase small subunit, swivel; SPTR: 3-isopropylmalate dehydratase, small subunit; TIGRFAM: 3-isopropylmalate dehydratase, small subunit, subgroup.
  
  
 0.777
leuD
3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily.
  
  
 0.777
ilvC
Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
 
  
 0.740
Your Current Organism:
Methanofollis liminatans
NCBI taxonomy Id: 28892
Other names: M. liminatans DSM 4140, Methanofollis liminatans DSM 4140, Methanofollis liminatans GKZPZ, Methanofollis liminatans str. DSM 4140, Methanofollis liminatans strain DSM 4140, Methanogenium liminatans (DSM 4140), Methanogenium liminatans DSM 4140
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