STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
trpBTryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (390 aa)    
Predicted Functional Partners:
trpA
Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family.
 0.999
EJG06044.1
PFAM: Indole-3-glycerol phosphate synthase; COGs: COG0134 Indole-3-glycerol phosphate synthase; InterPro IPR013798; KEGG: mem:Memar_0074 indole-3-glycerol-phosphate synthase; PFAM: Indole-3-glycerol phosphate synthase; SPTR: Indole-3-glycerol phosphate synthase.
 
 0.999
trpD
Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA).
 
 
 0.999
EJG06046.1
PFAM: Glutamine amidotransferase class-I; TIGRFAM: glutamine amidotransferase of anthranilate synthase or aminodeoxychorismate synthase; COGs: COG0512 Anthranilate/para-aminobenzoate synthase component II; InterPro IPR000991:IPR006221; KEGG: mbn:Mboo_0227 glutamine amidotransferase of anthranilate synthase; PFAM: Glutamine amidotransferase class-I, C-terminal; SPTR: Glutamine amidotransferase of anthranilate synthase; TIGRFAM: Glutamine amidotransferase of anthranilate synthase.
 
 
 0.999
EJG06047.1
PFAM: Anthranilate synthase component I, N terminal region; chorismate binding enzyme; COGs: COG0147 Anthranilate/para-aminobenzoate synthase component I; InterPro IPR006805:IPR015890; KEGG: mbn:Mboo_0228 anthranilate synthase; PFAM: Chorismate binding, C-terminal; Anthranilate synthase component I, N-terminal; SPTR: Anthranilate synthase.
 
  
 0.999
trpF
PFAM: N-(5'phosphoribosyl)anthranilate (PRA) isomerase; COGs: COG0135 Phosphoribosylanthranilate isomerase; InterPro IPR001240; KEGG: mem:Memar_0075 phosphoribosylanthranilate isomerase; PFAM: N-(5'phosphoribosyl)anthranilate isomerase (PRAI); SPTR: N-(5'-phosphoribosyl)anthranilate isomerase; Belongs to the TrpF family.
 
 0.996
trpB-2
Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine.
 
 
0.996
glyA
Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. Also exhibits THF-independent aldolase activity toward beta- hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
     
 0.988
trpF-2
PFAM: N-(5'phosphoribosyl)anthranilate (PRA) isomerase; COGs: COG0135 Phosphoribosylanthranilate isomerase; InterPro IPR001240; KEGG: mbn:Mboo_0224 phosphoribosylanthranilate isomerase; PFAM: N-(5'phosphoribosyl)anthranilate isomerase (PRAI); SPTR: N-(5'-phosphoribosyl)anthranilate isomerase; Belongs to the TrpF family.
 
 0.982
aroC
Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
  
  
 0.822
Your Current Organism:
Methanofollis liminatans
NCBI taxonomy Id: 28892
Other names: M. liminatans DSM 4140, Methanofollis liminatans DSM 4140, Methanofollis liminatans GKZPZ, Methanofollis liminatans str. DSM 4140, Methanofollis liminatans strain DSM 4140, Methanogenium liminatans (DSM 4140), Methanogenium liminatans DSM 4140
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