STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
ribH6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. (135 aa)    
Predicted Functional Partners:
EJG06082.1
Riboflavin synthase; PFAM: 6,7-dimethyl-8-ribityllumazine synthase; TIGRFAM: riboflavin synthase; COGs: COG1731 riboflavin synthase; InterPro IPR002180:IPR006399; KEGG: mpi:Mpet_0320 riboflavin synthase; PFAM: 6,7-dimethyl-8-ribityllumazine synthase; SPTR: Riboflavin synthase; TIGRFAM: Riboflavin synthase, archaeal.
 
  
  0.999
EJG08300.1
3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
 
 
 0.999
EJG07694.1
PFAM: RibD C-terminal domain; TIGRFAM: riboflavin-specific deaminase C-terminal domain; 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine 1'-reductase, archaeal; COGs: COG1985 Pyrimidine reductase riboflavin biosynthesis; InterPro IPR011549:IPR006401:IPR002734; KEGG: mem:Memar_2026 5-amino-6-(5-phosphoribosylamino)uracil reductase; PFAM: Bacterial bifunctional deaminase-reductase, C-terminal; SPTR: 2, 5-diamino-6-(5-phosphoribosylamino)pyrimidin-4(3H)-one reductase; TIGRFAM:2,5-diamino-6-hydroxy-4-(5- phosphoribosylamino)pyrimidine 1-reductase, archaeal; Riboflavin-specific dea [...]
 
 0.961
EJG06080.1
PFAM: Aminotransferase class I and II; COGs: COG0436 Aspartate/tyrosine/aromatic aminotransferase; InterPro IPR004839; KEGG: mbn:Mboo_0056 aspartate aminotransferase; PFAM: Aminotransferase, class I/II; SPTR: Aminotransferase, class I and II.
  
 
 0.946
EJG07858.1
PFAM: RibD C-terminal domain; TIGRFAM: riboflavin-specific deaminase C-terminal domain; COGs: COG1985 Pyrimidine reductase riboflavin biosynthesis; InterPro IPR011549:IPR002734; KEGG: mbn:Mboo_0908 5-amino-6-(5-phosphoribosylamino)uracil reductase; PFAM: Bacterial bifunctional deaminase-reductase, C-terminal; SPTR: 5-amino-6-(5-phosphoribosylamino)uracil reductase; TIGRFAM: Riboflavin-specific deaminase, C-terminal.
 
 0.928
EJG06083.1
PFAM: Aminotransferase class-V; COGs: COG0075 Serine-pyruvate aminotransferase/ aspartate aminotransferase; InterPro IPR000192; KEGG: mem:Memar_0056 aminotransferase, class V; PFAM: Aminotransferase, class V/Cysteine desulfurase; SPTR: Phosphoserine aminotransferase apoenzyme / L-aspartate aminotransferase apoenzyme.
 
   
 0.878
pyrB
PFAM: Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; TIGRFAM: aspartate carbamoyltransferase; COGs: COG0540 Aspartate carbamoyltransferase catalytic chain; HAMAP: Aspartate carbamoyltransferase; InterPro IPR006132:IPR006131:IPR002082; KEGG: mem:Memar_1689 aspartate carbamoyltransferase catalytic subunit; PFAM: Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding; Aspartate/ornithine carbamoyltransferase, Asp/Orn-binding region; SPTR: Aspartate carbamoyltransferase; TIGRFAM: Aspartate carba [...]
  
    0.875
rpl13
Ribosomal protein L13; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.
  
    0.851
cofG
FO synthase subunit 1; Catalyzes the radical-mediated synthesis of 7,8-didemethyl-8- hydroxy-5-deazariboflavin (FO) from 5-amino-5-(4-hydroxybenzyl)-6-(D- ribitylimino)-5,6-dihydrouracil.
  
  
 0.850
rpl6
Ribosomal protein L6P; This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center; Belongs to the universal ribosomal protein uL6 family.
   
    0.781
Your Current Organism:
Methanofollis liminatans
NCBI taxonomy Id: 28892
Other names: M. liminatans DSM 4140, Methanofollis liminatans DSM 4140, Methanofollis liminatans GKZPZ, Methanofollis liminatans str. DSM 4140, Methanofollis liminatans strain DSM 4140, Methanogenium liminatans (DSM 4140), Methanogenium liminatans DSM 4140
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