STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Cooccurrence
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[Homology]
Score
pdxSPyridoxal biosynthesis lyase pdxS; Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5- phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Belongs to the PdxS/SNZ family. (298 aa)    
Predicted Functional Partners:
pdxT
Glutamine amidotransferase subunit pdxT; Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS.
 0.999
prs
Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P).
   
 
  0.971
purA
Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.
  
  
 0.928
cobD
Cobalamin biosynthesis protein cbiB; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.
       0.885
EJG06109.1
Protein of unknown function DUF343; PFAM: Trm112p-like protein; InterPro IPR005651; KEGG: mem:Memar_0006 hypothetical protein; PFAM: Protein of unknown function DUF343; SPTR: Putative uncharacterized protein.
       0.877
EJG07494.1
Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine.
  
  
 0.811
EJG06108.1
KEGG: mem:Memar_0007 hypothetical protein; SPTR: Putative uncharacterized protein.
       0.748
EJG06014.1
Cysteate synthase; Specifically catalyzes the beta-elimination of phosphate from L-phosphoserine and the beta-addition of sulfite to the dehydroalanine intermediate to produce L-cysteate.
  
  
 0.692
EJG06858.1
PFAM: Archaeal phosphomethylpyrimidine kinase; COGs: COG1992 conserved hypothetical protein; InterPro IPR019293; KEGG: mem:Memar_1460 phosphomethylpyrimidine kinase; PFAM: Phosphomethylpyrimidine kinase; SPTR: Phosphomethylpyrimidine kinase.
    
 0.648
EJG07606.1
PFAM: Phosphomethylpyrimidine kinase; TIGRFAM: phosphomethylpyrimidine kinase; COGs: COG0351 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase; InterPro IPR004399:IPR013749; KEGG: mem:Memar_1226 phosphomethylpyrimidine kinase; PFAM: Phosphomethylpyrimidine kinase type-1; SPTR: Phosphomethylpyrimidine kinase; TIGRFAM: Phosphomethylpyrimidine kinase type-2.
    
 0.648
Your Current Organism:
Methanofollis liminatans
NCBI taxonomy Id: 28892
Other names: M. liminatans DSM 4140, Methanofollis liminatans DSM 4140, Methanofollis liminatans GKZPZ, Methanofollis liminatans str. DSM 4140, Methanofollis liminatans strain DSM 4140, Methanogenium liminatans (DSM 4140), Methanogenium liminatans DSM 4140
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