STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hel308Ski2-type helicase; DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks. (726 aa)    
Predicted Functional Partners:
fusA
Translation elongation factor aEF-2; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF [...]
   
 0.999
EJG08247.1
Like-Sm ribonucleoprotein core; PFAM: LSM domain; COGs: COG1958 Small nuclear ribonucleoprotein (snRNP) homolog; InterPro IPR006649:IPR001163; KEGG: mem:Memar_0230 like-Sm ribonucleoprotein, core; PFAM: Like-Sm ribonucleoprotein, core; SMART: Like-Sm ribonucleoprotein, core domain, eukaryotic/archaea-type; SPTR: Small nuclear ribonucleoprotein, LSM family.
  
 0.992
EJG06844.1
Like-Sm ribonucleoprotein core; PFAM: LSM domain; InterPro IPR006649:IPR001163; KEGG: mem:Memar_1564 like-Sm ribonucleoprotein, core; PFAM: Like-Sm ribonucleoprotein, core; SMART: Like-Sm ribonucleoprotein, core domain, eukaryotic/archaea-type; SPTR: Small nuclear ribonucleoprotein, LSM family.
   
 0.991
flpA
Fibrillarin-like rRNA/tRNA 2'-O-methyltransferase; Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA; Belongs to the methyltransferase superfamily. Fibrillarin family.
  
 
 0.965
EJG07404.1
DEAD/DEAH box helicase domain protein; PFAM: Helicase conserved C-terminal domain; DbpA RNA binding domain; DEAD/DEAH box helicase; COGs: COG0513 Superfamily II DNA and RNA helicase; InterPro IPR014001:IPR001650:IPR011545:IPR005580; KEGG: mem:Memar_1760 DEAD/DEAH box helicase domain-containing protein; PFAM: DNA/RNA helicase, DEAD/DEAH box type, N-terminal; DNA/RNA helicase, C-terminal; DbpA, RNA-binding; SMART: DEAD-like helicase, N-terminal; DNA/RNA helicase, C-terminal; SPTR: DEAD/DEAH box helicase domain protein; manually curated.
    
 0.957
rpl7ae
50S ribosomal protein L7Ae; Multifunctional RNA-binding protein that recognizes the K- turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs.
  
 
 
 0.944
EJG07306.1
PFAM: Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD; COGs: COG0652 Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family; InterPro IPR002130; KEGG: mma:MM_2829 peptidyl-prolyl cis-trans isomerase; PFAM: Peptidyl-prolyl cis-trans isomerase, cyclophilin-type; SPTR: Peptidyl-prolyl cis-trans isomerase.
   
 
 0.930
EJG06125.1
PFAM: KH domain; TIGRFAM: arCOG04150 universal archaeal KH domain protein; COGs: COG1094 RNA-binding protein (contains KH domains); InterPro IPR004087:IPR018111:IPR019964; KEGG: mpl:Mpal_2793 putative RNA-processing protein; SMART: K Homology; SPTR: KH type 1 domain protein; TIGRFAM: KH domain protein, archaea.
 
     0.784
EJG06117.1
PFAM: Kinase binding protein CGI-121; InterPro IPR007510; KEGG: mem:Memar_2502 hypothetical protein; SPTR: Putative uncharacterized protein.
       0.768
EJG06126.1
RIO-like kinase; PFAM: RIO1 family; COGs: COG1718 Serine/threonine protein kinase involved in cell cycle control; InterPro IPR000687:IPR018934; KEGG: mem:Memar_2499 protein of unknown function RIO1; PFAM: RIO-like kinase; SMART: RIO kinase; SPTR: Putative uncharacterized protein.
 
   0.696
Your Current Organism:
Methanofollis liminatans
NCBI taxonomy Id: 28892
Other names: M. liminatans DSM 4140, Methanofollis liminatans DSM 4140, Methanofollis liminatans GKZPZ, Methanofollis liminatans str. DSM 4140, Methanofollis liminatans strain DSM 4140, Methanogenium liminatans (DSM 4140), Methanogenium liminatans DSM 4140
Server load: low (24%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.