STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
EJG06167.1Type III restriction protein res subunit; PFAM: Armadillo/beta-catenin-like repeat; Helicase conserved C-terminal domain; Type III restriction enzyme, res subunit; COGs: COG1061 DNA or RNA helicase of superfamily II; InterPro IPR014001:IPR001650:IPR004155:IPR006935; KEGG: hla:Hlac_3022 type III restriction protein res subunit; PFAM: Restriction endonuclease, type I, R subunit/Type III, Res subunit; DNA/RNA helicase, C-terminal; PBS lyase HEAT-like repeat; SMART: DNA/RNA helicase, C-terminal; DEAD-like helicase, N-terminal; PBS lyase HEAT-like repeat; SPTR: Type III restriction protein [...] (858 aa)    
Predicted Functional Partners:
tfe
Transcription factor E; Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. Seems [...]
   
 0.989
EJG07107.1
DEAD_2 domain protein; PFAM: DEAD_2; COGs: COG1199 Rad3-related DNA helicase; InterPro IPR010614:IPR006554:IPR006555; KEGG: mpl:Mpal_1699 DEAD_2 domain protein; PFAM: DEAD2; SMART: Helicase, ATP-dependent, c2 type; Helicase-like, DEXD box c2 type; SPTR: DEAD_2 domain protein.
   
 0.987
rpoH
RNA polymerase Rpb5; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoH/eukaryotic RPB5 RNA polymerase subunit family.
    
 0.985
tfb
Transcription initiation factor IIB; Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).
    
 0.985
rpoD
DNA-directed RNA polymerase subunit D; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
  
 
 0.981
EJG06586.1
PFAM: RNA polymerase Rpb6; InterPro IPR006110; KEGG: mbn:Mboo_2217 RNA polymerase Rpb6; PFAM: RNA polymerase Rpb6; SPTR: RNA polymerase Rpb6; manually curated.
    
 0.977
rpoP
DNA-directed RNA polymerase subunit P; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoP/eukaryotic RPC10 RNA polymerase subunit family.
    
  0.975
rpoN
DNA-directed RNA polymerase subunit N; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoN/eukaryotic RPB10 RNA polymerase subunit family.
    
  0.974
EJG07855.1
PFAM: RNA polymerases M/15 Kd subunit; Transcription factor S-II (TFIIS); TIGRFAM: transcription factor S, archaeal; COGs: COG1594 DNA-directed RNA polymerase subunit M/Transcription elongation factor TFIIS; InterPro IPR001529:IPR001222:IPR006288; KEGG: mbn:Mboo_0911 transcription termination factor Tfs; PFAM: Zinc finger, TFIIS-type; DNA-directed RNA polymerase, M/15kDa subunit; SMART: Zinc finger, TFIIS-type; DNA-directed RNA polymerase, M/15kDa subunit; SPTR: Transcription termination factor Tfs; TIGRFAM: DNA-directed RNA polymerase, subunit M, archaeal; Belongs to the archaeal rpoM [...]
    
 0.966
EJG05993.1
Hypothetical protein; COGs: COG1310 metal-dependent protease of the PAD1/JAB1 superfamily; KEGG: mpl:Mpal_0311 hypothetical protein; SPTR: Putative uncharacterized protein.
  
 
  0.868
Your Current Organism:
Methanofollis liminatans
NCBI taxonomy Id: 28892
Other names: M. liminatans DSM 4140, Methanofollis liminatans DSM 4140, Methanofollis liminatans GKZPZ, Methanofollis liminatans str. DSM 4140, Methanofollis liminatans strain DSM 4140, Methanogenium liminatans (DSM 4140), Methanogenium liminatans DSM 4140
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