STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
polCDNA polymerase II large subunit; Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase. (1288 aa)    
Predicted Functional Partners:
polB
Metallophosphoesterase; Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase; Belongs to the DNA polymerase delta/II small subunit family.
 
 
 
 0.991
pcn
DNA polymerase sliding clamp; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.
 
 
 
 0.977
EJG06114.1
Cell division control protein 6-like protein; Involved in regulation of DNA replication.
 
   
 0.752
EJG06203.1
PFAM: PBS lyase HEAT-like repeat; InterPro IPR004155; KEGG: mbn:Mboo_0125 heat repeat-containing PBS lyase; PFAM: PBS lyase HEAT-like repeat; SPTR: PBS lyase HEAT domain protein repeat-containing protein.
       0.730
spt5
NusG antitermination factor; Stimulates transcription elongation; Belongs to the archaeal Spt5 family.
  
     0.729
EJG07119.1
Geranylgeranylglyceryl phosphate synthase; Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids.
       0.726
EJG06684.1
Phosphoesterase RecJ domain protein; PFAM: DHH family; DHHA1 domain; COGs: COG0608 Single-stranded DNA-specific exonuclease; InterPro IPR001667:IPR003156; KEGG: mem:Memar_1684 phosphoesterase, DHHA1; PFAM: Phosphoesterase, RecJ-like; Phosphoesterase, DHHA1; SPTR: Phosphoesterase, DHHA1.
 
     0.717
EJG07593.1
PFAM: Protein of unknown function (DUF424); COGs: COG2412 conserved hypothetical protein; InterPro IPR007355; KEGG: mem:Memar_1239 hypothetical protein; PFAM: Protein of unknown function DUF424; SPTR: Putative uncharacterized protein.
 
     0.712
EJG07891.1
PFAM: PAC2 family; TIGRFAM: TIGR00162 family protein; COGs: COG2047 conserved hypothetical protein (ATP-grasp superfamily); InterPro IPR004426:IPR002766; KEGG: mpi:Mpet_1769 hypothetical protein; SPTR: Putative uncharacterized protein; TIGRFAM: Conserved hypothetical protein CHP00062.
  
     0.706
EJG07761.1
PFAM: Protein of unknown function, DUF655; COGs: COG1491 RNA-binding protein; InterPro IPR007003; KEGG: mem:Memar_1959 hypothetical protein; PFAM: Protein of unknown function DUF655; SPTR: Putative uncharacterized protein.
  
     0.699
Your Current Organism:
Methanofollis liminatans
NCBI taxonomy Id: 28892
Other names: M. liminatans DSM 4140, Methanofollis liminatans DSM 4140, Methanofollis liminatans GKZPZ, Methanofollis liminatans str. DSM 4140, Methanofollis liminatans strain DSM 4140, Methanogenium liminatans (DSM 4140), Methanogenium liminatans DSM 4140
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.