STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
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[Homology]
Score
mptAProtein of unknown function DUF198; Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin. (311 aa)    
Predicted Functional Partners:
EJG07937.1
TIGRFAM: anaerobic ribonucleoside-triphosphate reductase; COGs: COG1328 Oxygen-sensitive ribonucleoside-triphosphate reductase; InterPro IPR012833; KEGG: mem:Memar_0320 anaerobic ribonucleoside-triphosphate reductase; SPTR: Anaerobic ribonucleoside-triphosphate reductase; TIGRFAM: Ribonucleoside-triphosphate reductase, anaerobic.
  
  
  0.972
ndk
Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
    
  0.971
EJG07529.1
Forkhead-associated protein; PFAM: FHA domain; InterPro IPR000253; KEGG: mem:Memar_1770 FHA domain-containing protein; PFAM: Forkhead-associated; SMART: Forkhead-associated; SPTR: Transcriptional regulator, ArsR family.
    
  0.921
EJG08051.1
PFAM: Bacterial regulatory protein, arsR family; FHA domain; InterPro IPR001845:IPR000253; KEGG: mem:Memar_1770 FHA domain-containing protein; PFAM: Forkhead-associated; HTH transcriptional regulator, ArsR; SMART: Forkhead-associated; HTH transcriptional regulator, ArsR; SPTR: Transcriptional regulator, ArsR family.
    
  0.921
EJG06319.1
Queuosine biosynthesis protein QueD; PFAM: 6-pyruvoyl tetrahydropterin synthase; TIGRFAM: queuosine biosynthesis protein QueD; 6-pyruvoyl tetrahydropterin synthase/QueD family protein; COGs: COG0720 6-pyruvoyl-tetrahydropterin synthase; InterPro IPR007115; KEGG: mem:Memar_2208 putative 6-pyruvoyl tetrahydropterin synthase; PFAM: 6-pyruvoyl tetrahydropterin synthase-related; SPTR: Putative uncharacterized protein; TIGRFAM: queuosine biosynthesis protein QueD.
    
 0.779
mptE
Protein of unknown function DUF115; Catalyzes the transfer of diphosphate from ATP to 6- hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6-hydroxymethyl- 7,8-dihydropterin diphosphate (6-HMDP); Belongs to the archaeal 6-HMPDK family.
 
   
 0.686
EJG07835.1
Metal dependent phosphohydrolase; PFAM: HD domain; OB-fold nucleic acid binding domain; TIGRFAM: uncharacterized domain HDIG; COGs: COG3481 HD-superfamily hydrolase; InterPro IPR003607:IPR006675:IPR004365:IPR006674; KEGG: mem:Memar_1871 metal dependent phosphohydrolase; PFAM: Metal-dependent phosphohydrolase, HD region, subdomain; Nucleic acid binding, OB-fold, tRNA/helicase-type; SMART: Metal-dependent phosphohydrolase, HD region; SPTR: Metal dependent phosphohydrolase; TIGRFAM: HDIG.
  
  
 0.660
EJG06676.1
Hexapeptide repeat-containing transferase; COGs: COG0663 Carbonic anhydrase/acetyltransferase isoleucine patch superfamily; InterPro IPR001451; KEGG: mem:Memar_1692 hexapaptide repeat-containing transferase; SPTR: Transferase hexapeptide repeat containing protein.
  
  
 0.658
EJG07551.1
PFAM: NIF3 (NGG1p interacting factor 3); TIGRFAM: dinuclear metal center protein, YbgI/SA1388 family; COGs: COG0327 conserved hypothetical protein; InterPro IPR002678; KEGG: mbn:Mboo_1271 hypothetical protein; PFAM: NGG1p interacting factor 3, NIF3; SPTR: Putative uncharacterized protein; TIGRFAM: NGG1p interacting factor 3, NIF3.
 
  
  0.655
EJG08067.1
Ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
 
  
  0.649
Your Current Organism:
Methanofollis liminatans
NCBI taxonomy Id: 28892
Other names: M. liminatans DSM 4140, Methanofollis liminatans DSM 4140, Methanofollis liminatans GKZPZ, Methanofollis liminatans str. DSM 4140, Methanofollis liminatans strain DSM 4140, Methanogenium liminatans (DSM 4140), Methanogenium liminatans DSM 4140
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