STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
radBDNA repair and recombination protein RadB; Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange. (231 aa)    
Predicted Functional Partners:
fen
Flap structure-specific endonuclease; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair [...]
  
 0.909
pcn
DNA polymerase sliding clamp; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.
 
 0.906
EJG08297.1
PFAM: OB-fold nucleic acid binding domain; COGs: COG1599 Single-stranded DNA-binding replication protein A (RPA) large (70 kD) subunit and related ssDNA-binding protein; InterPro IPR004365; KEGG: mhu:Mhun_2542 nucleic acid binding, OB-fold, tRNA/helicase-type; PFAM: Nucleic acid binding, OB-fold, tRNA/helicase-type; SPTR: Nucleic acid binding, OB-fold, tRNA/helicase-type.
 
 0.857
EJG06346.1
PFAM: Protein of unknown function DUF111; TIGRFAM: TIGR00299 family protein; COGs: COG1641 conserved hypothetical protein; InterPro IPR002822; KEGG: mpl:Mpal_0261 hypothetical protein; PFAM: Protein of unknown function DUF111; SPTR: Putative uncharacterized protein; TIGRFAM: Protein of unknown function DUF111; Belongs to the LarC family.
       0.854
EJG07089.1
PFAM: DNA polymerase family B; DNA polymerase family B, exonuclease domain; COGs: COG0417 DNA polymerase elongation subunit (family B); InterPro IPR006133:IPR006134:IPR006172; KEGG: mem:Memar_0798 DNA polymerase B region; PFAM: DNA-directed DNA polymerase, family B, conserved region; DNA-directed DNA polymerase, family B, exonuclease domain; SMART: DNA-directed DNA polymerase, family B; SPTR: DNA polymerase.
 
 0.826
EJG07813.1
PFAM: OB-fold nucleic acid binding domain; COGs: COG1599 Single-stranded DNA-binding replication protein A (RPA) large (70 kD) subunit and related ssDNA-binding protein; InterPro IPR004365; KEGG: mbn:Mboo_2098 nucleic acid binding, OB-fold, tRNA/helicase-type; PFAM: Nucleic acid binding, OB-fold, tRNA/helicase-type; SPTR: Nucleic acid binding, OB-fold, tRNA/helicase-type.
  
 0.826
EJG07101.1
ATP-dependent DNA helicase, RecQ family; PFAM: Helicase conserved C-terminal domain; RQC domain; DEAD/DEAH box helicase; TIGRFAM: ATP-dependent DNA helicase RecQ; ATP-dependent DNA helicase, RecQ family; COGs: COG0514 Superfamily II DNA helicase; InterProIPR011545:IPR001650:IPR018982:IPR018329:IPR 014001; KEGG: mpl:Mpal_2442 ATP-dependent DNA helicase RecQ; PFAM: DNA/RNA helicase, C-terminal; DNA/RNA helicase, DEAD/DEAH box type, N-terminal; RQC domain; SMART: DEAD-like helicase, N-terminal; DNA/RNA helicase, C-terminal; SPTR: ATP-dependent DNA helicase RecQ; TIGRFAM: DNA helicase, ATP [...]
  
 0.812
EJG07400.1
ATP-dependent DNA helicase RecQ; PFAM: Helicase conserved C-terminal domain; RQC domain; HRDC domain; DEAD/DEAH box helicase; TIGRFAM: ATP-dependent DNA helicase RecQ; ATP-dependent DNA helicase, RecQ family; COGs: COG0514 Superfamily II DNA helicase; InterProIPR006293:IPR018329:IPR014001:IPR001650:IPR 002121:IPR011545:IPR018982; KEGG: mpl:Mpal_2442 ATP-dependent DNA helicase RecQ; PFAM: DNA/RNA helicase, DEAD/DEAH box type, N-terminal; DNA/RNA helicase, C-terminal; RQC domain; Helicase/RNase D C-terminal, HRDC domain; SMART: DEAD-like helicase, N-terminal; DNA/RNA helicase, C-terminal [...]
  
 0.812
EJG06345.1
AAA family ATPase, CDC48 subfamily; PFAM: Cell division protein 48 (CDC48), N-terminal domain; ATPase family associated with various cellular activities (AAA); Cell division protein 48 (CDC48), domain 2; TIGRFAM: AAA family ATPase, CDC48 subfamily; COGs: COG0464 ATPase of the AAA+ class; InterProIPR005938:IPR003338:IPR004201:IPR003959:IPR 003593; KEGG: mem:Memar_2157 AAA family ATPase, CDC48 subfamily protein; PFAM: ATPase, AAA-type, core; ATPase, AAA-type, VAT, N-terminal; Cell division protein 48, CDC48, domain 2; SMART: ATPase, AAA+ type, core; SPTR: AAA family ATPase, CDC48 subfami [...]
  
 
 0.797
EJG06165.1
PFAM: UvrD/REP helicase; COGs: COG0210 Superfamily I DNA and RNA helicase; InterPro IPR000212; KEGG: mel:Metbo_1561 UvrD/REP helicase; PFAM: DNA helicase, UvrD/REP type; SPTR: UvrD/REP helicase family protein.
  
 
 0.786
Your Current Organism:
Methanofollis liminatans
NCBI taxonomy Id: 28892
Other names: M. liminatans DSM 4140, Methanofollis liminatans DSM 4140, Methanofollis liminatans GKZPZ, Methanofollis liminatans str. DSM 4140, Methanofollis liminatans strain DSM 4140, Methanogenium liminatans (DSM 4140), Methanogenium liminatans DSM 4140
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