Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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gene co-occurrence
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trm1N(2),N(2)-dimethylguanosine tRNA methyltransferase; Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups; Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family. (372 aa)    
Predicted Functional Partners:
truB
rRNA pseudouridine synthase; Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs; Belongs to the pseudouridine synthase TruB family. Type 2 subfamily.
  
 
 0.901
EJG06393.1
PFAM: Putative snoRNA binding domain; COGs: COG1498 Protein implicated in ribosomal biogenesis Nop56p homolog; InterPro IPR002687; KEGG: mem:Memar_0541 pre-mRNA processing ribonucleoprotein, binding region; PFAM: Pre-mRNA processing ribonucleoprotein, binding region; SPTR: rRNA biogenesis protein Nop56/Nop58.
 
    0.876
pus10
Conserved hypothetical protein CHP01213; Responsible for synthesis of pseudouridine from uracil-54 and uracil-55 in the psi GC loop of transfer RNAs.
  
   
 0.830
EJG07636.1
Methanogenesis marker domain 9; PFAM: Dihydrouridine synthase (Dus); TIGRFAM: TIM-barrel protein, putative; putative methanogenesis marker domain 9; COGs: COG4008 metal-binding transcription factor; InterPro IPR017671; KEGG: mem:Memar_1729 hypothetical protein; SPTR: Putative uncharacterized protein; TIGRFAM: Putative methanogenesis marker domain 9.
  
 
 0.781
rpl24
Ribosomal protein L24; Located at the polypeptide exit tunnel on the outside of the subunit.
  
 
   0.777
EJG07589.1
PFAM: Putative RNA methylase family UPF0020; TIGRFAM: TIGR01177 family protein; COGs: COG1041 DNA modification methylase; InterPro IPR000241; KEGG: mem:Memar_1059 putative RNA methylase; PFAM: Putative RNA methylase; SPTR: N2-methylguanosine tRNA methyltransferase.
  
 
 0.772
thiI
tRNA sulfurtransferase; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
      
 0.734
flpA
Fibrillarin-like rRNA/tRNA 2'-O-methyltransferase; Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA; Belongs to the methyltransferase superfamily. Fibrillarin family.
 
 
 0.732
EJG07765.1
Methylase; PFAM: Methyltransferase small domain; TIGRFAM: HemK-related putative methylase; COGs: COG2890 Methylase of polypeptide chain release factors; InterPro IPR004557:IPR013216; KEGG: mem:Memar_1957 putative methylase; PFAM: Methyltransferase type 11; SPTR: Putative methylase; TIGRFAM: Putative methylase.
  
 
 
 0.730
truD
tRNA pseudouridine synthase D; Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs; Belongs to the pseudouridine synthase TruD family.
 
 
 0.720
Your Current Organism:
Methanofollis liminatans
NCBI taxonomy Id: 28892
Other names: M. liminatans DSM 4140, Methanofollis liminatans DSM 4140, Methanofollis liminatans GKZPZ, Methanofollis liminatans str. DSM 4140, Methanofollis liminatans strain DSM 4140, Methanogenium liminatans (DSM 4140), Methanogenium liminatans DSM 4140
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