STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
thiItRNA sulfurtransferase; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. (392 aa)    
Predicted Functional Partners:
EJG07344.1
PFAM: Aminotransferase class-V; COGs: COG1104 Cysteine sulfinate desulfinase/cysteine desulfurase; InterPro IPR000192; KEGG: mpl:Mpal_1672 aminotransferase class V; PFAM: Aminotransferase, class V/Cysteine desulfurase; SPTR: Aminotransferase class V.
  
 0.984
iscS
Cysteine desulfurase NifS; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins.
  
 0.984
EJG06768.1
Conserved hypothetical protein CHP00268; PFAM: Asparagine synthase; TIGRFAM: TIGR00268 family protein; COGs: COG1606 ATP-utilizing protein of the PP-loop superfamily; InterPro IPR001962:IPR005232; KEGG: mem:Memar_1612 ExsB family protein; PFAM: Asparagine synthase; SPTR: ExsB family protein; TIGRFAM: Conserved hypothetical protein CHP00268.
     
 0.852
EJG06769.1
PFAM: Dinitrogenase iron-molybdenum cofactor; COGs: COG1433 conserved hypothetical protein; InterPro IPR003731; KEGG: ton:TON_0921 iron-molybdenum cofactor-binding protein; PFAM: Dinitrogenase iron-molybdenum cofactor biosynthesis; SPTR: Iron-molybdenum cofactor-binding protein.
       0.773
EJG08172.1
UBA/THIF-type NAD/FAD binding protein; PFAM: MoeZ/MoeB domain; ThiF family; COGs: COG0476 Dinucleotide-utilizing protein involved in molybdopterin and thiamine biosynthesis family 2; InterPro IPR000594:IPR007901; KEGG: mem:Memar_1336 UBA/ThiF-type NAD/FAD binding protein; PFAM: UBA/THIF-type NAD/FAD binding fold; MoeZ/MoeB; SPTR: UBA/THIF-type NAD/FAD binding protein.
    
 0.758
EJG07086.1
MiaB-like tRNA modifying enzyme; PFAM: TRAM domain; Radical SAM superfamily; Uncharacterized protein family UPF0004; TIGRFAM: MiaB-like tRNA modifying enzyme, archaeal-type; radical SAM methylthiotransferase, MiaB/RimO family; COGs: COG0621 2-methylthioadenine synthetase; InterProIPR013848:IPR007197:IPR002792:IPR005839:IPR 006466:IPR006638; KEGG: mpi:Mpet_2689 MiaB-like tRNA modifying enzyme; PFAM: Radical SAM; Methylthiotransferase, N-terminal; Deoxyribonuclease/rho motif-related TRAM; SMART: Elongator protein 3/MiaB/NifB; SPTR: MiaB-like tRNA modifying enzyme; TIGRFAM: MiaB-like tRNA [...]
   
  
 0.654
EJG06771.1
COGs: COG1202 Superfamily II helicase; KEGG: mem:Memar_1610 superfamily II helicase-like protein; SPTR: Superfamily II helicase-like protein.
 
     0.599
pdxS
Pyridoxal biosynthesis lyase pdxS; Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5- phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Belongs to the PdxS/SNZ family.
     
 0.582
EJG08027.1
Protein of unknown function UPF0021; PFAM: PP-loop family; TIGRFAM: TIGR00269 family protein; COGs: COG0037 ATPase of the PP-loop superfamily protein implicated in cell cycle control; InterPro IPR000541:IPR011063; KEGG: mpi:Mpet_2592 phosphoadenosine phosphosulfate reductase; PFAM: PP-loop; SPTR: Phosphoadenosine phosphosulfate reductase; TIGRFAM: Uncharacterised protein family UPF0021, C-terminal.
  
  
 0.578
EJG06244.1
Rhodanese-like protein; PFAM: Metallo-beta-lactamase superfamily; Rhodanese-like domain; COGs: COG0607 Rhodanese-related sulfurtransferase; InterPro IPR001763; KEGG: mpi:Mpet_2048 rhodanese domain-containing protein; PFAM: Rhodanese-like; SMART: Rhodanese-like; SPTR: Rhodanese domain protein.
    
 0.575
Your Current Organism:
Methanofollis liminatans
NCBI taxonomy Id: 28892
Other names: M. liminatans DSM 4140, Methanofollis liminatans DSM 4140, Methanofollis liminatans GKZPZ, Methanofollis liminatans str. DSM 4140, Methanofollis liminatans strain DSM 4140, Methanogenium liminatans (DSM 4140), Methanogenium liminatans DSM 4140
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