STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
EJG06815.1PFAM: Histidine biosynthesis protein; TIGRFAM: hisA/hisF family protein; COGs: COG1411 Uncharacterized protein related to proFAR isomerase (HisA); InterPro IPR006062; KEGG: mpl:Mpal_2062 histidine biosynthesis protein; PFAM: Histidine biosynthesis; SPTR: Histidine biosynthesis protein; manually curated. (221 aa)    
Predicted Functional Partners:
hisF
Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
     
 0.984
hisA
1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino) imidazole-4-carboxamide isomerase; PFAM: Histidine biosynthesis protein; TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; COGs: COG0106 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase; HAMAP:1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; InterPro IPR006062:IPR006063; KEGG: mbn:Mboo_1066 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; PFAM: Histi [...]
     
 0.983
tmk
PFAM: Thymidylate kinase; TIGRFAM: thymidylate kinase; COGs: COG0125 Thymidylate kinase; HAMAP: Thymidylate kinase; InterPro IPR000062:IPR018094; KEGG: mem:Memar_1571 thymidylate kinase; PFAM: Thymidylate kinase-like; SPTR: Probable thymidylate kinase; TIGRFAM: Thymidylate kinase.
       0.945
mfnB
UPF0264 protein; Catalyzes the formation of 4-(hydroxymethyl)-2- furancarboxaldehyde phosphate (4-HFC-P) from two molecules of glyceraldehyde-3-P (GA-3-P).
 
   
 0.941
EJG06251.1
PFAM: Amino acid kinase family; COGs: COG2054 Uncharacterized kinase related to aspartokinase uridylate kinase; InterPro IPR001048; KEGG: mpl:Mpal_2593 aspartate/glutamate/uridylate kinase; PFAM: Aspartate/glutamate/uridylate kinase; SPTR: Aspartate/glutamate/uridylate kinase.
 
   
 0.846
EJG07847.1
TIGRFAM: probable H4MPT-linked C1 transfer pathway protein; COGs: COG1548 transcriptional regulator/sugar kinase; InterPro IPR002756; KEGG: mbn:Mboo_0921 hypothetical protein; SPTR: Putative uncharacterized protein; TIGRFAM: Tetrahydromethanopterin-linked C1 transfer pathway, putative.
 
   
 0.846
ftr
formylmethanofuran/tetrahydromethanopterinN-form yltransferase; Catalyzes the reversible transfer of a formyl group from formylmethanofuran (formyl-MFR) to tetrahydromethanopterin (H(4)MPT) so as to produce 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) and methanofuran (MFR); Belongs to the FTR family.
 
     0.830
EJG07848.1
ATP-grasp fold domain protein, DUF201-type; PFAM: ATP-grasp domain; COGs: COG1821 ATP-utilizing protein (ATP-grasp superfamily); InterPro IPR003806; KEGG: mpl:Mpal_0581 protein of unknown function DUF201; PFAM: ATP-grasp fold, DUF201-type; SPTR: Putative uncharacterized protein.
 
     0.815
EJG06472.1
PFAM: Amidohydrolase family; TIGRFAM: formylmethanofuran dehydrogenase subunit A; COGs: COG1229 Formylmethanofuran dehydrogenase subunit A; InterPro IPR012027:IPR013108; KEGG: mem:Memar_0619 amidohydrolase 3; PFAM: Amidohydrolase 3; SPTR: Formylmethanofuran dehydrogenase, subunit A; TIGRFAM: Formylmethanofuran dehydrogenase, subunit A.
 
     0.772
EJG06961.1
PFAM: Amidohydrolase family; TIGRFAM: formylmethanofuran dehydrogenase subunit A; COGs: COG1229 Formylmethanofuran dehydrogenase subunit A; InterPro IPR013108:IPR012027; KEGG: mem:Memar_1188 amidohydrolase 3; PFAM: Amidohydrolase 3; SPTR: Formylmethanofuran dehydrogenase, subunit A; TIGRFAM: Formylmethanofuran dehydrogenase, subunit A.
 
     0.771
Your Current Organism:
Methanofollis liminatans
NCBI taxonomy Id: 28892
Other names: M. liminatans DSM 4140, Methanofollis liminatans DSM 4140, Methanofollis liminatans GKZPZ, Methanofollis liminatans str. DSM 4140, Methanofollis liminatans strain DSM 4140, Methanogenium liminatans (DSM 4140), Methanogenium liminatans DSM 4140
Server load: low (32%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.