STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
hypAHydrogenase expression/synthesis HypA; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase. (113 aa)    
Predicted Functional Partners:
EJG06877.1
PFAM: HupF/HypC family; TIGRFAM: hydrogenase assembly chaperone HypC/HupF; COGs: COG0298 Hydrogenase maturation factor; InterPro IPR001109; KEGG: mbn:Mboo_1411 hydrogenase assembly chaperone HypC/HupF; PFAM: Hydrogenase expression/formation protein, HupF/HypC; SPTR: Hydrogenase assembly chaperone hypC/hupF; TIGRFAM: Hydrogenase expression/formation protein, HupF/HypC.
 
  
 0.979
EJG06879.1
Hydrogenase expression/formation protein HypE; PFAM: AIR synthase related protein, N-terminal domain; AIR synthase related protein, C-terminal domain; TIGRFAM: hydrogenase expression/formation protein HypE; COGs: COG0309 Hydrogenase maturation factor; InterPro IPR000728:IPR010918:IPR011854; KEGG: mem:Memar_1022 hydrogenase expression/formation protein HypE; PFAM: AIR synthase related protein, C-terminal; AIR synthase related protein; SPTR: Hydrogenase expression/formation protein HypE; TIGRFAM: Hydrogenase expression/formation protein HypE.
 
  
 0.976
EJG08039.1
Hydrogenase accessory protein HypB; PFAM: CobW/HypB/UreG, nucleotide-binding domain; TIGRFAM: hydrogenase accessory protein HypB; COGs: COG0378 Ni2+-binding GTPase involved in regulation of expression and maturation of urease and hydrogenase; InterPro IPR004392:IPR003495; KEGG: mem:Memar_0470 hydrogenase accessory protein HypB; PFAM: Cobalamin (vitamin B12) biosynthesis CobW-like; SPTR: Hydrogenase accessory protein HypB; TIGRFAM: Hydrogenase accessory protein HypB.
 
 
 0.961
EJG07719.1
PFAM: Nickel-dependent hydrogenase; COGs: COG3259 Coenzyme F420-reducing hydrogenase alpha subunit; InterPro IPR001501; KEGG: mem:Memar_1007 nickel-dependent hydrogenase, large subunit; PFAM: Nickel-dependent hydrogenase, large subunit; SPTR: F420-non-reducing hydrogenase subunit A; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.
  
 
 0.950
EJG08108.1
ATPase-like, ParA/MinD; Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP; Belongs to the Mrp/NBP35 ATP-binding proteins family.
   
 
 0.943
EJG06220.1
PFAM: Nickel-dependent hydrogenase; TIGRFAM: coenzyme F420 hydrogenase, subunit alpha; COGs: COG3259 Coenzyme F420-reducing hydrogenase alpha subunit; InterPro IPR001501:IPR017682; KEGG: mem:Memar_2174 nickel-dependent hydrogenase, large subunit; PFAM: Nickel-dependent hydrogenase, large subunit; SPTR: Coenzyme F420-reducing hydrogenase, alpha subunit; TIGRFAM: Coenzyme F420 hydrogenase, subunit alpha; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.
 
 
 0.897
EJG06011.1
Cobalamin synthesis protein P47K; PFAM: CobW/HypB/UreG, nucleotide-binding domain; COGs: COG0378 Ni2+-binding GTPase involved in regulation of expression and maturation of urease and hydrogenase; InterPro IPR003593:IPR003495; KEGG: mem:Memar_0108 cobalamin synthesis protein, P47K; PFAM: Cobalamin (vitamin B12) biosynthesis CobW-like; SMART: ATPase, AAA+ type, core; SPTR: Cobalamin synthesis protein, P47K.
 
 
 0.883
EJG07217.1
PFAM: Hydrogenase formation hypA family; TIGRFAM: hydrogenase expression/formation protein HypD; COGs: COG0409 Hydrogenase maturation factor; InterPro IPR002780; KEGG: mbn:Mboo_1301 hydrogenase expression/formation protein HypD; PFAM: Hydrogenase formation HypD protein; SPTR: Hydrogenase expression/formation protein HypD; TIGRFAM: Hydrogenase formation HypD protein.
 
  
 0.778
EJG08148.1
(NiFe) hydrogenase maturation protein HypF; PFAM: HypF finger; yrdC domain; Acylphosphatase; TIGRFAM: [NiFe] hydrogenase maturation protein HypF; COGs: COG0068 Hydrogenase maturation factor; InterPro IPR001792:IPR011125:IPR006070:IPR004421; KEGG: mem:Memar_0417 (NiFe) hydrogenase maturation protein HypF; PFAM: Sua5/YciO/YrdC, N-terminal; Acylphosphatase-like; Zinc finger, HypF-type; SPTR: (NiFe) hydrogenase maturation protein HypF; TIGRFAM: Hydrogenase maturation factor, HypF-type.
 
   
 0.739
pyrC
Dihydroorotase, multifunctional complex type; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
       0.725
Your Current Organism:
Methanofollis liminatans
NCBI taxonomy Id: 28892
Other names: M. liminatans DSM 4140, Methanofollis liminatans DSM 4140, Methanofollis liminatans GKZPZ, Methanofollis liminatans str. DSM 4140, Methanofollis liminatans strain DSM 4140, Methanogenium liminatans (DSM 4140), Methanogenium liminatans DSM 4140
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