STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
EJG07068.1PFAM: S-adenosylmethionine synthetase (AdoMet synthetase); COGs: COG1812 S-adenosylmethionine synthetase; InterPro IPR002795; KEGG: mem:Memar_0838 S-adenosylmethionine synthetase; PFAM: S-adenosylmethionine synthetase (MAT), archaea; SPTR: Methionine adenosyltransferase. (401 aa)    
Predicted Functional Partners:
EJG06342.1
PFAM: Cobalamin-independent synthase, Catalytic domain; COGs: COG0620 Methionine synthase II (cobalamin-independent); InterPro IPR002629; KEGG: mem:Memar_2152 methionine synthase; PFAM: Methionine synthase, vitamin-B12 independent; SPTR: Methionine synthase (B12-independent).
  
  
 0.985
hisG
ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
 
    0.934
hisA
1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino) imidazole-4-carboxamide isomerase; PFAM: Histidine biosynthesis protein; TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; COGs: COG0106 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase; HAMAP:1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; InterPro IPR006062:IPR006063; KEGG: mbn:Mboo_1066 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; PFAM: Histi [...]
       0.914
hisB
PFAM: Imidazoleglycerol-phosphate dehydratase; COGs: COG0131 Imidazoleglycerol-phosphate dehydratase; HAMAP: Imidazoleglycerol-phosphate dehydratase; InterPro IPR000807; KEGG: mpl:Mpal_1747 imidazoleglycerol-phosphate dehydratase; PFAM: Imidazoleglycerol-phosphate dehydratase; SPTR: Imidazoleglycerol-phosphate dehydratase.
       0.870
gap
PFAM: Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; TIGRFAM: glyceraldehyde-3-phosphate dehydrogenase, type II; COGs: COG0057 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase; HAMAP: Glyceraldehyde-3-phosphate dehydrogenase; InterPro IPR020828:IPR020829:IPR006436; KEGG: mpl:Mpal_2790 glyceraldehyde-3-phosphate dehydrogenase; PFAM: Glyceraldehyde 3-phosphate dehydrogenase, NAD(P) binding domain; Glyceraldehyde 3-phosphate dehydrogenase, catalytic domain; SPTR: Glyceraldehyde-3-phosph [...]
  
  
  0.620
EJG06978.1
PFAM: S-adenosylmethionine decarboxylase; InterPro IPR003826; KEGG: mem:Memar_2178 hypothetical protein; PFAM: S-adenosylmethionine decarboxylase, bacterial/archaeal; SPTR: Putative uncharacterized protein.
     
 0.611
tpiA
Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family.
  
  
  0.604
EJG06080.1
PFAM: Aminotransferase class I and II; COGs: COG0436 Aspartate/tyrosine/aromatic aminotransferase; InterPro IPR004839; KEGG: mbn:Mboo_0056 aspartate aminotransferase; PFAM: Aminotransferase, class I/II; SPTR: Aminotransferase, class I and II.
  
  
 0.577
EJG07385.1
PFAM: Aminotransferase class I and II; COGs: COG0436 Aspartate/tyrosine/aromatic aminotransferase; InterPro IPR004839; KEGG: mbn:Mboo_1200 aminotransferase, class I and II; PFAM: Aminotransferase, class I/II; SPTR: Aminotransferase, class I and II.
  
  
 0.575
pgk
PFAM: Phosphoglycerate kinase; COGs: COG0126 3-phosphoglycerate kinase; HAMAP: Phosphoglycerate kinase; InterPro IPR001576; KEGG: mbn:Mboo_2342 phosphoglycerate kinase; PFAM: Phosphoglycerate kinase; SPTR: Phosphoglycerate kinase 2; Belongs to the phosphoglycerate kinase family.
  
  
  0.564
Your Current Organism:
Methanofollis liminatans
NCBI taxonomy Id: 28892
Other names: M. liminatans DSM 4140, Methanofollis liminatans DSM 4140, Methanofollis liminatans GKZPZ, Methanofollis liminatans str. DSM 4140, Methanofollis liminatans strain DSM 4140, Methanogenium liminatans (DSM 4140), Methanogenium liminatans DSM 4140
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