Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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[Homology]
Score
EJG07068.1PFAM: S-adenosylmethionine synthetase (AdoMet synthetase); COGs: COG1812 S-adenosylmethionine synthetase; InterPro IPR002795; KEGG: mem:Memar_0838 S-adenosylmethionine synthetase; PFAM: S-adenosylmethionine synthetase (MAT), archaea; SPTR: Methionine adenosyltransferase. (401 aa)    
Predicted Functional Partners:
EJG06342.1
PFAM: Cobalamin-independent synthase, Catalytic domain; COGs: COG0620 Methionine synthase II (cobalamin-independent); InterPro IPR002629; KEGG: mem:Memar_2152 methionine synthase; PFAM: Methionine synthase, vitamin-B12 independent; SPTR: Methionine synthase (B12-independent).
  
  
 0.949
hisG
ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
 
    0.928
hisA
1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino) imidazole-4-carboxamide isomerase; PFAM: Histidine biosynthesis protein; TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; COGs: COG0106 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase; HAMAP:1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; InterPro IPR006062:IPR006063; KEGG: mbn:Mboo_1066 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; PFAM: Histi [...]
       0.911
hisB
PFAM: Imidazoleglycerol-phosphate dehydratase; COGs: COG0131 Imidazoleglycerol-phosphate dehydratase; HAMAP: Imidazoleglycerol-phosphate dehydratase; InterPro IPR000807; KEGG: mpl:Mpal_1747 imidazoleglycerol-phosphate dehydratase; PFAM: Imidazoleglycerol-phosphate dehydratase; SPTR: Imidazoleglycerol-phosphate dehydratase.
       0.910
EJG06978.1
PFAM: S-adenosylmethionine decarboxylase; InterPro IPR003826; KEGG: mem:Memar_2178 hypothetical protein; PFAM: S-adenosylmethionine decarboxylase, bacterial/archaeal; SPTR: Putative uncharacterized protein.
     
 0.781
EJG07161.1
Adenylyl cyclase CyaB; PFAM: CYTH domain; TIGRFAM: adenylyl cyclase CyaB, putative; COGs: COG1437 Adenylate cyclase class 2 (thermophilic); InterPro IPR008172:IPR008173; KEGG: mpl:Mpal_1572 adenylyl cyclase CyaB; PFAM: Adenylate cyclase; SPTR: Adenylyl cyclase CyaB; TIGRFAM: Adenylyl cyclase CyaB.
 
     0.753
EJG07160.1
PFAM: FKBP-type peptidyl-prolyl cis-trans isomerase; COGs: COG1047 FKBP-type peptidyl-prolyl cis-trans isomerase 2; InterPro IPR001179; KEGG: mpl:Mpal_1571 peptidylprolyl isomerase FKBP-type; PFAM: Peptidyl-prolyl cis-trans isomerase, FKBP-type; SPTR: Peptidylprolyl isomerase FKBP-type.
  
  
 0.714
thiI
tRNA sulfurtransferase; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
 
     0.675
EJG08301.1
PFAM: MarR family; Domain of unknown function DUF120; COGs: COG1339 Transcriptional regulator of a riboflavin/FAD biosynthetic operon; InterPro IPR000835:IPR002834; KEGG: mbn:Mboo_0159 hypothetical protein; PFAM: Riboflavin kinase, CTP-dependent, archaeal; HTH transcriptional regulator, MarR; SPTR: Riboflavin kinase.
 
     0.622
EJG08302.1
Transcriptional regulator, XRE family; PFAM: Helix-turn-helix; COGs: COG1709 transcriptional regulator protein; InterPro IPR001387; KEGG: mem:Memar_2360 helix-turn-helix domain-containing protein; PFAM: Helix-turn-helix type 3; SMART: Helix-turn-helix type 3; SPTR: Transcriptional regulator, XRE family.
  
     0.546
Your Current Organism:
Methanofollis liminatans
NCBI taxonomy Id: 28892
Other names: M. liminatans DSM 4140, Methanofollis liminatans DSM 4140, Methanofollis liminatans GKZPZ, Methanofollis liminatans str. DSM 4140, Methanofollis liminatans strain DSM 4140, Methanogenium liminatans (DSM 4140), Methanogenium liminatans DSM 4140
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