STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
EJG07106.1methylated-DNA/protein- cysteinemethyltransferase; PFAM: 6-O-methylguanine DNA methyltransferase, DNA binding domain; TIGRFAM: O-6-methylguanine DNA methyltransferase; COGs: COG0350 Methylated DNA-protein cysteine methyltransferase; InterPro IPR014048; KEGG: mem:Memar_0790 methylated-DNA--protein-cysteine methyltransferase; PFAM: Methylated-DNA-[protein]-cysteine S-methyltransferase, DNA binding; SPTR: Methylated-DNA--protein-cysteine methyltransferase; TIGRFAM: Methylated-DNA-[protein]-cysteine S-methyltransferase, DNA binding. (144 aa)    
Predicted Functional Partners:
EJG07107.1
DEAD_2 domain protein; PFAM: DEAD_2; COGs: COG1199 Rad3-related DNA helicase; InterPro IPR010614:IPR006554:IPR006555; KEGG: mpl:Mpal_1699 DEAD_2 domain protein; PFAM: DEAD2; SMART: Helicase, ATP-dependent, c2 type; Helicase-like, DEXD box c2 type; SPTR: DEAD_2 domain protein.
 
   
 0.965
EJG07104.1
PFAM: Glycosyl transferase family 2; COGs: COG0746 Molybdopterin-guanine dinucleotide biosynthesis protein A; KEGG: mem:Memar_0792 molybdopterin-guanine dinucleotide biosynthesis protein A; SPTR: Molybdenum cofactor guanylyltransferase.
     
 0.908
dtdA
D-tyrosyl-tRNA(Tyr) deacylase; D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo.
       0.844
EJG06523.1
PFAM: 8-oxoguanine DNA glycosylase, N-terminal domain; HhH-GPD superfamily base excision DNA repair protein; TIGRFAM: 8-oxoguanine DNA-glycosylase (ogg); COGs: COG0122 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase; InterPro IPR012904:IPR003265; KEGG: mbn:Mboo_0662 8-oxoguanine DNA glycosylase domain-containing protein; PFAM: 8-oxoguanine DNA glycosylase, N-terminal; HhH-GPD domain; SMART: HhH-GPD domain; SPTR: 8-oxoguanine DNA glycosylase domain protein.
  
 
 0.805
EJG07105.1
2-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.
       0.800
EJG08255.1
PFAM: 2Fe-2S iron-sulfur cluster binding domain; Cysteine-rich domain; TIGRFAM: succinate dehydrogenase and fumarate reductase iron-sulfur protein; COGs: COG0247 Fe-S oxidoreductase; InterPro IPR001041:IPR004017:IPR004489; KEGG: mem:Memar_0220 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; PFAM: Cysteine-rich region, CCG; Ferredoxin; SPTR: Thiol-driven fumarate reductase, iron-sulfur protein; TIGRFAM: Succinate dehydrogenase/fumarate reductase iron-sulphur protein.
       0.759
EJG06134.1
Putative signal transduction histidine kinase; PFAM: Natural resistance-associated macrophage protein; 5TMR of 5TMR-LYT; COGs: COG3275 Putative regulator of cell autolysis; InterPro IPR011620; KEGG: mpi:Mpet_2152 signal transduction histidine kinase LytS; PFAM: Signal transduction histidine kinase, 5TM receptor LytS, transmembrane region; SPTR: Signal transduction histidine kinase, LytS.
       0.746
EJG08231.1
Peptidase S8 and S53 subtilisin kexin sedolisin; PFAM: Cohesin domain; CARDB; Subtilase family; COGs: COG1404 Subtilisin-like serine protease; InterPro IPR000209:IPR002102; KEGG: afu:AF1653 alkaline serine protease (AprM); PFAM: Peptidase S8/S53, subtilisin/kexin/sedolisin; Cellulosome anchoring protein, cohesin region; SPTR: Alkaline serine protease (AprM); Belongs to the peptidase S8 family.
       0.724
nth
Endonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate.
 
   
 0.643
ruvB
Holliday junction ATP-dependent DNA helicase ruvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing.
 
   
 0.592
Your Current Organism:
Methanofollis liminatans
NCBI taxonomy Id: 28892
Other names: M. liminatans DSM 4140, Methanofollis liminatans DSM 4140, Methanofollis liminatans GKZPZ, Methanofollis liminatans str. DSM 4140, Methanofollis liminatans strain DSM 4140, Methanogenium liminatans (DSM 4140), Methanogenium liminatans DSM 4140
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