STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
EJG07258.1PFAM: UvrD/REP helicase; COGs: COG1074 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains); InterPro IPR000212; KEGG: mem:Memar_1498 UvrD/REP helicase; PFAM: DNA helicase, UvrD/REP type; SPTR: UvrD/REP helicase. (1128 aa)    
Predicted Functional Partners:
EJG07257.1
COGs: COG3857 ATP-dependent nuclease subunit B; KEGG: mem:Memar_1499 ATP-dependent nuclease subunit B-like protein; SPTR: ATP-dependent nuclease subunit B-like protein.
 
     0.981
EJG07101.1
ATP-dependent DNA helicase, RecQ family; PFAM: Helicase conserved C-terminal domain; RQC domain; DEAD/DEAH box helicase; TIGRFAM: ATP-dependent DNA helicase RecQ; ATP-dependent DNA helicase, RecQ family; COGs: COG0514 Superfamily II DNA helicase; InterProIPR011545:IPR001650:IPR018982:IPR018329:IPR 014001; KEGG: mpl:Mpal_2442 ATP-dependent DNA helicase RecQ; PFAM: DNA/RNA helicase, C-terminal; DNA/RNA helicase, DEAD/DEAH box type, N-terminal; RQC domain; SMART: DEAD-like helicase, N-terminal; DNA/RNA helicase, C-terminal; SPTR: ATP-dependent DNA helicase RecQ; TIGRFAM: DNA helicase, ATP [...]
  
 0.842
EJG07400.1
ATP-dependent DNA helicase RecQ; PFAM: Helicase conserved C-terminal domain; RQC domain; HRDC domain; DEAD/DEAH box helicase; TIGRFAM: ATP-dependent DNA helicase RecQ; ATP-dependent DNA helicase, RecQ family; COGs: COG0514 Superfamily II DNA helicase; InterProIPR006293:IPR018329:IPR014001:IPR001650:IPR 002121:IPR011545:IPR018982; KEGG: mpl:Mpal_2442 ATP-dependent DNA helicase RecQ; PFAM: DNA/RNA helicase, DEAD/DEAH box type, N-terminal; DNA/RNA helicase, C-terminal; RQC domain; Helicase/RNase D C-terminal, HRDC domain; SMART: DEAD-like helicase, N-terminal; DNA/RNA helicase, C-terminal [...]
  
 0.842
mutL
DNA mismatch repair protein mutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.
 
 
 
 0.827
uvrB
UvrABC system protein B; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and [...]
 
 
 0.811
radB
DNA repair and recombination protein RadB; Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange.
  
 
 0.786
radA
DNA repair and recombination protein radA; Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules.
  
 
 0.786
pcn
DNA polymerase sliding clamp; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.
  
 
 0.785
EJG07255.1
PFAM: Protein of unknown function (DUF2791); KEGG: plm:Plim_1077 hypothetical protein; SPTR: Putative uncharacterized protein.
  
 
 0.764
EJG07682.1
Helicase domain-containing protein; PFAM: Helicase conserved C-terminal domain; DEAD/DEAH box helicase; COGs: COG1111 ERCC4-like helicase; InterProIPR011545:IPR001650:IPR006166:IPR000445:IPR 014001:IPR003583; KEGG: mem:Memar_1418 Hef nuclease; PFAM: DNA/RNA helicase, C-terminal; DNA/RNA helicase, DEAD/DEAH box type, N-terminal; ERCC4 domain; Helix-hairpin-helix motif; SMART: DEAD-like helicase, N-terminal; DNA/RNA helicase, C-terminal; Helix-hairpin-helix DNA-binding motif, class 1; SPTR: Helicase domain protein.
    
 
 0.736
Your Current Organism:
Methanofollis liminatans
NCBI taxonomy Id: 28892
Other names: M. liminatans DSM 4140, Methanofollis liminatans DSM 4140, Methanofollis liminatans GKZPZ, Methanofollis liminatans str. DSM 4140, Methanofollis liminatans strain DSM 4140, Methanogenium liminatans (DSM 4140), Methanogenium liminatans DSM 4140
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