STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
EJG07380.1CRISPR-associated HD domain protein; PFAM: Helicase conserved C-terminal domain; DEAD/DEAH box helicase; TIGRFAM: CRISPR-associated endonuclease Cas3-HD; COGs: COG1203 helicase; InterPro IPR006483:IPR001650; KEGG: dhd:Dhaf_2186 CRISPR-associated HD domain protein; PFAM: DNA/RNA helicase, C-terminal; SMART: DNA/RNA helicase, C-terminal; SPTR: CRISPR-associated HD domain protein; TIGRFAM: CRISPR-associated HD domain. (726 aa)    
Predicted Functional Partners:
EJG07383.1
PFAM: CRISPR-associated protein (Cas_Cas5); TIGRFAM: CRISPR-associated protein Cas5, N-terminal domain; InterPro IPR013422:IPR010155; KEGG: dhd:Dhaf_2183 CRISPR-associated protein Cas5; PFAM: CRISPR-associated protein, Cas5d-type; SPTR: CRISPR-associated protein Cas5; TIGRFAM: CRISPR-associated protein Cas5; manually curated.
 
 
 0.977
EJG07381.1
CRISPR-associated protein TM1801; PFAM: Family of unknown function (DUF694); TIGRFAM: CRISPR-associated protein, CT1132 family; COGs: COG3649 Uncharacterized protein predicted to be involved in DNA repair; InterPro IPR006482; KEGG: dhd:Dhaf_2185 CRISPR-associated protein TM1801; PFAM: CRISPR-associated protein TM1801; SPTR: Crispr-protein.
 
  
 0.957
EJG08368.1
PFAM: CRISPR-associated protein (Cas_Cas5); TIGRFAM: CRISPR-associated protein Cas5, subtype I-C/DVULG; CRISPR-associated protein Cas5, N-terminal domain; InterPro IPR010155:IPR013422; KEGG: tjr:TherJR_1889 CRISPR-associated protein Cas5 family; PFAM: CRISPR-associated protein, Cas5d-type; SPTR: CRISPR-associated protein Cas5 family; TIGRFAM: CRISPR-associated protein, Cas5d-type; CRISPR-associated protein Cas5.
 
 
 0.877
cas1
CRISPR-associated protein Cas1; CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
 
  
 0.849
cas2
CRISPR-associated protein Cas2; CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
 
  
 0.847
EJG07379.1
CRISPR-associated protein Cas4; CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Belongs to the CRISPR-associated exonuclease Cas4 family.
 
  
 0.808
EJG08366.1
PFAM: Family of unknown function (DUF694); TIGRFAM: CRISPR-associated protein, CT1132 family; CRISPR-associated protein Cas7/Csd2, subtype I-C/DVULG; COGs: COG3649 Uncharacterized protein predicted to be involved in DNA repair; InterPro IPR006482:IPR013418; KEGG: tjr:TherJR_1887 CRISPR-associated protein, Csd2 family; PFAM: CRISPR-associated protein TM1801; SPTR: CRISPR-associated protein, Csd2 family; TIGRFAM: CRISPR-associated protein Csd2; CRISPR-associated protein TM1801.
 
  
 0.745
cas1-3
CRISPR-associated protein Cas1; CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
 
  
 0.716
cas2-2
CRISPR-associated protein Cas2; CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
 
  
 0.710
EJG07382.1
KEGG: dhd:Dhaf_2184 hypothetical protein; SPTR: Putative uncharacterized protein.
       0.709
Your Current Organism:
Methanofollis liminatans
NCBI taxonomy Id: 28892
Other names: M. liminatans DSM 4140, Methanofollis liminatans DSM 4140, Methanofollis liminatans GKZPZ, Methanofollis liminatans str. DSM 4140, Methanofollis liminatans strain DSM 4140, Methanogenium liminatans (DSM 4140), Methanogenium liminatans DSM 4140
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