STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
EJG07510.1Orc1/cdc6 family replication initiation protein; Involved in regulation of DNA replication. (374 aa)    
Predicted Functional Partners:
EJG07419.1
PFAM: MCM2/3/5 family; COGs: COG1241 ATPase involved in replication control Cdc46/Mcm family; InterPro IPR001208; KEGG: mpi:Mpet_0979 MCM family protein; PFAM: DNA-dependent ATPase MCM; SMART: DNA-dependent ATPase MCM; SPTR: MCM family protein; Belongs to the MCM family.
 
 0.931
EJG07418.1
PFAM: MCM2/3/5 family; COGs: COG1241 ATPase involved in replication control Cdc46/Mcm family; InterPro IPR001208; KEGG: mpi:Mpet_0979 MCM family protein; PFAM: DNA-dependent ATPase MCM; SMART: DNA-dependent ATPase MCM; SPTR: MCM family protein; Belongs to the MCM family.
 
 0.929
EJG07089.1
PFAM: DNA polymerase family B; DNA polymerase family B, exonuclease domain; COGs: COG0417 DNA polymerase elongation subunit (family B); InterPro IPR006133:IPR006134:IPR006172; KEGG: mem:Memar_0798 DNA polymerase B region; PFAM: DNA-directed DNA polymerase, family B, conserved region; DNA-directed DNA polymerase, family B, exonuclease domain; SMART: DNA-directed DNA polymerase, family B; SPTR: DNA polymerase.
  
 0.731
priL
DNA primase, large subunit; Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.
  
 
 0.716
pcn
DNA polymerase sliding clamp; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.
  
  
 0.689
EJG07813.1
PFAM: OB-fold nucleic acid binding domain; COGs: COG1599 Single-stranded DNA-binding replication protein A (RPA) large (70 kD) subunit and related ssDNA-binding protein; InterPro IPR004365; KEGG: mbn:Mboo_2098 nucleic acid binding, OB-fold, tRNA/helicase-type; PFAM: Nucleic acid binding, OB-fold, tRNA/helicase-type; SPTR: Nucleic acid binding, OB-fold, tRNA/helicase-type.
  
 
 0.672
priS
DNA primase small subunit; Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. [...]
  
 
 0.670
EJG06818.1
PFAM: Bacterial regulatory protein, arsR family; COGs: COG1777 transcriptional regulator protein; InterPro IPR001845; KEGG: mpl:Mpal_2059 transcriptional regulator, ArsR family; PFAM: HTH transcriptional regulator, ArsR; SMART: HTH transcriptional regulator, ArsR; SPTR: Transcriptional regulator, ArsR family.
  
     0.664
mch
Methenyltetrahydromethanopterin cyclohydrolase; Catalyzes the reversible interconversion of 5-formyl-H(4)MPT to methenyl-H(4)MPT(+); Belongs to the MCH family.
     
 0.621
EJG08029.1
PFAM: Protein of unknown function (DUF460); COGs: COG2433 conserved hypothetical protein; InterPro IPR007408; KEGG: mem:Memar_0481 hypothetical protein; PFAM: Protein of unknown function DUF460; SPTR: Putative uncharacterized protein.
  
     0.615
Your Current Organism:
Methanofollis liminatans
NCBI taxonomy Id: 28892
Other names: M. liminatans DSM 4140, Methanofollis liminatans DSM 4140, Methanofollis liminatans GKZPZ, Methanofollis liminatans str. DSM 4140, Methanofollis liminatans strain DSM 4140, Methanogenium liminatans (DSM 4140), Methanogenium liminatans DSM 4140
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