STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
iscSCysteine desulfurase NifS; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins. (388 aa)    
Predicted Functional Partners:
EJG07678.1
PFAM: NifU-like N terminal domain; TIGRFAM: FeS cluster assembly scaffold protein NifU, Clostridium type; COGs: COG0822 NifU homolog involved in Fe-S cluster formation; InterPro IPR002871; KEGG: cbf:CLI_2630 putative iron-sulfur cluster assembly protein; PFAM: NIF system FeS cluster assembly, NifU, N-terminal; SPTR: FeS cluster assembly scaffold protein NifU.
 
 0.999
EJG07345.1
PFAM: NifU-like N terminal domain; TIGRFAM: FeS cluster assembly scaffold IscU; FeS cluster assembly scaffold protein NifU, Clostridium type; COGs: COG0822 NifU homolog involved in Fe-S cluster formation; InterPro IPR017787:IPR002871; KEGG: mpl:Mpal_1673 FeS cluster assembly scaffold protein NifU; PFAM: NIF system FeS cluster assembly, NifU, N-terminal; SPTR: FeS cluster assembly scaffold protein NifU; TIGRFAM: NIF system FeS cluster assembly, NifU-like.
 
 0.997
thiI
tRNA sulfurtransferase; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
  
 0.984
EJG07342.1
PFAM: SirA-like protein; InterPro IPR001455; KEGG: mpl:Mpal_1670 SirA family protein; PFAM: SirA-like; SPTR: SirA family protein.
   
 0.971
EJG08172.1
UBA/THIF-type NAD/FAD binding protein; PFAM: MoeZ/MoeB domain; ThiF family; COGs: COG0476 Dinucleotide-utilizing protein involved in molybdopterin and thiamine biosynthesis family 2; InterPro IPR000594:IPR007901; KEGG: mem:Memar_1336 UBA/ThiF-type NAD/FAD binding protein; PFAM: UBA/THIF-type NAD/FAD binding fold; MoeZ/MoeB; SPTR: UBA/THIF-type NAD/FAD binding protein.
   
 0.942
EJG06510.1
PFAM: Bacterial regulatory protein, arsR family; V4R domain; COGs: COG1719 hydrocarbon binding protein (contains V4R domain); InterPro IPR001845:IPR004096; KEGG: mem:Memar_0431 4-vinyl reductase, 4VR; PFAM: 4-vinyl reductase, 4VR; HTH transcriptional regulator, ArsR; SMART: HTH transcriptional regulator, ArsR; SPTR: Transcriptional regulator, ArsR family.
       0.745
EJG07809.1
PFAM: FdhD/NarQ family; TIGRFAM: formate dehydrogenase family accessory protein FdhD; COGs: COG1526 Uncharacterized protein required for formate dehydrogenase activity; InterPro IPR003786; KEGG: mem:Memar_1911 formate dehydrogenase family accessory protein FdhD; PFAM: Formate dehydrogenase, subunit FdhD; SPTR: Formate dehydrogenase family accessory protein FdhD; TIGRFAM: Formate dehydrogenase, subunit FdhD.
  
 0.678
EJG07596.1
PFAM: DNA / pantothenate metabolism flavoprotein; Flavoprotein; TIGRFAM: phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase, prokaryotic; COGs: COG0452 Phosphopantothenoylcysteine synthetase/decarboxylase; InterPro IPR005252:IPR003382:IPR007085; KEGG: mem:Memar_1236 phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase; PFAM: Flavoprotein; DNA/pantothenate metabolism flavoprotein, C-terminal; SPTR: Phosphopantothenate-cysteine ligase; TIGRFAM: Bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase.
  
  0.631
EJG08257.1
Glutaredoxin-like protein, YruB-family; PFAM: Pyridine nucleotide-disulphide oxidoreductase; Glutaredoxin; TIGRFAM: thioredoxin-disulfide reductase; Glutaredoxin-like protein, YruB-family; COGs: COG3634 Alkyl hydroperoxide reductase large subunit; InterPro IPR002109:IPR013027:IPR011911; KEGG: mbn:Mboo_0084 glutaredoxin; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; Glutaredoxin; SPTR: Glutaredoxin; TIGRFAM: Glutaredoxin-like protein, YruB.
  
 
 0.623
EJG08382.1
PFAM: Aminotransferase class-V; TIGRFAM: cysteine desulfurase family protein; COGs: COG0520 Selenocysteine lyase; InterPro IPR000192; KEGG: mem:Memar_0881 aminotransferase, class V; PFAM: Aminotransferase, class V/Cysteine desulfurase; SPTR: Aminotransferase, class V.
 
  
0.608
Your Current Organism:
Methanofollis liminatans
NCBI taxonomy Id: 28892
Other names: M. liminatans DSM 4140, Methanofollis liminatans DSM 4140, Methanofollis liminatans GKZPZ, Methanofollis liminatans str. DSM 4140, Methanofollis liminatans strain DSM 4140, Methanogenium liminatans (DSM 4140), Methanogenium liminatans DSM 4140
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