STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
EJG07817.1Transcription factor CBF/NF-Y/histone domain-containing protein; PFAM: Histone-like transcription factor (CBF/NF-Y) and archaeal histone; COGs: COG2036 Histones H3 and H4; InterPro IPR003958; KEGG: mem:Memar_1921 transcription factor CBF/NF-Y histone; PFAM: Transcription factor CBF/NF-Y/archaeal histone; SPTR: Archaeal histone. (69 aa)    
Predicted Functional Partners:
thrS
PFAM: Anticodon binding domain; tRNA synthetase class II core domain (G, H, P, S and T); Archaea-specific editing domain of threonyl-tRNA synthetase; TIGRFAM: threonyl-tRNA synthetase; COGs: COG0441 Threonyl-tRNA synthetase; InterPro IPR015011:IPR002314:IPR004154:IPR002320; KEGG: mpl:Mpal_1303 threonyl-tRNA synthetase; PFAM: Threonyl-tRNA synthetase, editing region, archaea; Aminoacyl-tRNA synthetase, class II (G/ H/ P/ S), conserved region; Anticodon-binding; SPTR: Threonyl-tRNA synthetase; TIGRFAM: Threonyl-tRNA synthetase, class IIa; Belongs to the class-II aminoacyl-tRNA synthetase [...]
  
    0.629
tfe
Transcription factor E; Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. Seems [...]
  
   
 0.581
EJG07818.1
Putative signal transduction protein with CBS domains; PFAM: Domain of unknown function; CBS domain; COGs: COG2524 transcriptional regulator protein; InterPro IPR000644:IPR005104; KEGG: mpl:Mpal_0054 putative signal transduction protein with CBS domains; PFAM: Protein of unknown function DUF293, archaea; Cystathionine beta-synthase, core; SMART: Cystathionine beta-synthase, core; SPTR: Putative signal transduction protein with CBS domains.
 
     0.576
EJG07816.1
PFAM: PRC-barrel domain; InterPro IPR007903; KEGG: mpl:Mpal_0042 PRC-barrel domain protein; PFAM: PRC-barrel; SPTR: PRC-barrel domain protein.
  
    0.563
EJG07813.1
PFAM: OB-fold nucleic acid binding domain; COGs: COG1599 Single-stranded DNA-binding replication protein A (RPA) large (70 kD) subunit and related ssDNA-binding protein; InterPro IPR004365; KEGG: mbn:Mboo_2098 nucleic acid binding, OB-fold, tRNA/helicase-type; PFAM: Nucleic acid binding, OB-fold, tRNA/helicase-type; SPTR: Nucleic acid binding, OB-fold, tRNA/helicase-type.
 
  
 0.560
albA
DNA/RNA-binding protein Alba; Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes; Belongs to the histone-like Alba family.
  
   
 0.518
EJG07708.1
Conserved hypothetical protein CHP00061; PFAM: PAC2 family; TIGRFAM: TIGR00161 family protein; COGs: COG1938 protein of ATP-grasp superfamily; InterPro IPR004425:IPR002766; KEGG: mpl:Mpal_0692 protein of unknown function DUF75; SPTR: Putative uncharacterized protein; TIGRFAM: Conserved hypothetical protein CHP00061.
  
     0.515
sepS
O-phosphoseryl-tRNA(Cys) synthetase; Catalyzes the attachment of O-phosphoserine (Sep) to tRNA(Cys).
  
     0.507
EJG08157.1
PFAM: DHH family; DHHA1 domain; COGs: COG0608 Single-stranded DNA-specific exonuclease; InterPro IPR001667:IPR003156; KEGG: mem:Memar_0429 phosphoesterase domain-containing protein; PFAM: Phosphoesterase, DHHA1; Phosphoesterase, RecJ-like; SPTR: Phosphoesterase, RecJ domain protein.
  
     0.501
EJG07713.1
PFAM: Type II/IV secretion system protein; PIN domain; COGs: COG1855 ATPase (PilT family); InterPro IPR002716:IPR006596:IPR003593; KEGG: mem:Memar_2007 ATPase; PFAM: PilT protein, N-terminal; SMART: Nucleotide binding protein, PINc; ATPase, AAA+ type, core; SPTR: ATPase, PilT family.
  
     0.478
Your Current Organism:
Methanofollis liminatans
NCBI taxonomy Id: 28892
Other names: M. liminatans DSM 4140, Methanofollis liminatans DSM 4140, Methanofollis liminatans GKZPZ, Methanofollis liminatans str. DSM 4140, Methanofollis liminatans strain DSM 4140, Methanogenium liminatans (DSM 4140), Methanogenium liminatans DSM 4140
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