STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
EJG07861.1Protein of unknown function UPF0099; PFAM: Peptidyl-tRNA hydrolase PTH2; TIGRFAM: peptidyl-tRNA hydrolase; COGs: COG1990 conserved hypothetical protein; InterPro IPR002833; KEGG: mem:Memar_1400 peptidyl-tRNA hydrolase; PFAM: Peptidyl-tRNA hydrolase, PTH2; SPTR: Peptidyl-tRNA hydrolase; TIGRFAM: Peptidyl-tRNA hydrolase, PTH2. (120 aa)    
Predicted Functional Partners:
truD
tRNA pseudouridine synthase D; Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs; Belongs to the pseudouridine synthase TruD family.
 
     0.953
EJG06153.1
PFAM: Queuine tRNA-ribosyltransferase; TIGRFAM: tRNA-guanine transglycosylases, various specificities; COGs: COG0343 Queuine/archaeosine tRNA-ribosyltransferase; InterPro IPR002616; KEGG: ton:TON_0617 7-cyano-7-deazaguanine tRNA-ribosyltransferase; PFAM: Queuine/other tRNA-ribosyltransferase; SPTR: 7-cyano-7-deazaguanine tRNA-ribosyltransferase; TIGRFAM: Queuine/other tRNA-ribosyltransferase; manually curated.
 
     0.796
rpl22
Ribosomal protein L22; The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
  
    0.657
fen
Flap structure-specific endonuclease; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair [...]
 
     0.655
rpoD
DNA-directed RNA polymerase subunit D; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
  
    0.643
rps3ae
PFAM: Ribosomal S3Ae family; COGs: COG1890 Ribosomal protein S3AE; HAMAP: 30S ribosomal protein S3Ae; InterPro IPR001593; KEGG: mpi:Mpet_2009 30S ribosomal protein S3Ae; PFAM: Ribosomal protein S3Ae; SPTR: Ribosomal protein S3Ae; Belongs to the eukaryotic ribosomal protein eS1 family.
  
     0.613
rpl4
50S ribosomal protein L4P; Forms part of the polypeptide exit tunnel.
  
     0.610
rpoH
RNA polymerase Rpb5; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoH/eukaryotic RPB5 RNA polymerase subunit family.
 
    0.595
EJG06393.1
PFAM: Putative snoRNA binding domain; COGs: COG1498 Protein implicated in ribosomal biogenesis Nop56p homolog; InterPro IPR002687; KEGG: mem:Memar_0541 pre-mRNA processing ribonucleoprotein, binding region; PFAM: Pre-mRNA processing ribonucleoprotein, binding region; SPTR: rRNA biogenesis protein Nop56/Nop58.
  
    0.591
EJG07862.1
Geranylgeranyl reductase; PFAM: Lycopene cyclase protein; FAD binding domain; TIGRFAM: geranylgeranyl reductase family; COGs: COG0644 Dehydrogenase (flavoprotein); InterPro IPR011777:IPR013027; KEGG: mbn:Mboo_1166 geranylgeranyl reductase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; SPTR: Geranylgeranyl reductase; TIGRFAM: Geranylgeranyl reductase, plant/prokaryotic.
       0.575
Your Current Organism:
Methanofollis liminatans
NCBI taxonomy Id: 28892
Other names: M. liminatans DSM 4140, Methanofollis liminatans DSM 4140, Methanofollis liminatans GKZPZ, Methanofollis liminatans str. DSM 4140, Methanofollis liminatans strain DSM 4140, Methanogenium liminatans (DSM 4140), Methanogenium liminatans DSM 4140
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