STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
EJG07862.1Geranylgeranyl reductase; PFAM: Lycopene cyclase protein; FAD binding domain; TIGRFAM: geranylgeranyl reductase family; COGs: COG0644 Dehydrogenase (flavoprotein); InterPro IPR011777:IPR013027; KEGG: mbn:Mboo_1166 geranylgeranyl reductase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; SPTR: Geranylgeranyl reductase; TIGRFAM: Geranylgeranyl reductase, plant/prokaryotic. (385 aa)    
Predicted Functional Partners:
EJG06671.1
Digeranylgeranylglyceryl phosphate synthase; Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids.
 
 
 0.827
EJG06999.1
PFAM: UbiA prenyltransferase family; COGs: COG0382 4-hydroxybenzoate polyprenyltransferase and related prenyltransferase; InterPro IPR000537; KEGG: mpl:Mpal_1338 prenyltransferase; PFAM: UbiA prenyltransferase; SPTR: UbiA prenyltransferase.
 
 
 0.819
EJG06578.1
PFAM: Polyprenyl synthetase; COGs: COG0142 Geranylgeranyl pyrophosphate synthase; InterPro IPR000092; KEGG: mem:Memar_1816 geranyltranstransferase; PFAM: Polyprenyl synthetase; SPTR: Geranylgeranyl-diphosphate synthase / farnesyl-diphosphate synthase; Belongs to the FPP/GGPP synthase family.
 
 0.689
EJG07455.1
PFAM: CobN/Magnesium Chelatase; TIGRFAM: cobaltochelatase, CobN subunit; COGs: COG1429 Cobalamin biosynthesis protein CobN and related Mg-chelatase; InterPro IPR003672; KEGG: mpi:Mpet_0623 cobaltochelatase; PFAM: CobN/magnesium chelatase; SPTR: Magnesium chelatase family protein.
 
  
 0.663
EJG06642.1
PFAM: UbiA prenyltransferase family; InterPro IPR000537; KEGG: mem:Memar_1715 prenyltransferase; PFAM: UbiA prenyltransferase; SPTR: UbiA prenyltransferase.
  
 
 0.652
EJG07454.1
PFAM: von Willebrand factor type A domain; MCM2/3/5 family; COGs: COG1239 Mg-chelatase subunit ChlI; InterPro IPR003593:IPR002035:IPR011704; KEGG: mhu:Mhun_0291 magnesium chelatase, ChlI subunit; PFAM: von Willebrand factor, type A; ATPase associated with various cellular activities, AAA-5; SMART: von Willebrand factor, type A; ATPase, AAA+ type, core; SPTR: Protoporphyrin IX magnesium-chelatase.
  
  
 0.643
EJG07898.1
Digeranylgeranylglycerophospholipid reductase; Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3- diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di- O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains.
  
  
 
0.623
carS
UPF0290 protein; Catalyzes the formation of CDP-2,3-bis-(O-geranylgeranyl)-sn- glycerol (CDP-archaeol) from 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1- phosphate (DGGGP) and CTP. This reaction is the third ether-bond- formation step in the biosynthesis of archaeal membrane lipids.
  
  
 0.613
EJG06066.1
Digeranylgeranylglycerophospholipid reductase; Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3- diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di- O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains.
  
  
 
0.610
EJG07863.1
Cobalamin (vitamin B12) biosynthesis CbiM protein; PFAM: Cobalt uptake substrate-specific transmembrane region; TIGRFAM: cobalamin biosynthesis protein CbiM; COGs: COG0310 ABC-type Co2+ transport system permease component; InterPro IPR002751; KEGG: mhu:Mhun_1480 cobalt transport protein CbiM; PFAM: Cobalamin (vitamin B12) biosynthesis CbiM; SPTR: Cobalamin (Vitamin B12) biosynthesis CbiM protein.
       0.607
Your Current Organism:
Methanofollis liminatans
NCBI taxonomy Id: 28892
Other names: M. liminatans DSM 4140, Methanofollis liminatans DSM 4140, Methanofollis liminatans GKZPZ, Methanofollis liminatans str. DSM 4140, Methanofollis liminatans strain DSM 4140, Methanogenium liminatans (DSM 4140), Methanogenium liminatans DSM 4140
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.