node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EJG06094.1 | EJG07089.1 | Metli_0116 | Metli_1132 | TIGRFAM: signal peptidase I, archaeal type; InterPro IPR001733; KEGG: mem:Memar_0046 peptidase S26B, signal peptidase; SPTR: Peptidase S26B, signal peptidase; TIGRFAM: Peptidase S26B, eukaryotic signal peptidase. | PFAM: DNA polymerase family B; DNA polymerase family B, exonuclease domain; COGs: COG0417 DNA polymerase elongation subunit (family B); InterPro IPR006133:IPR006134:IPR006172; KEGG: mem:Memar_0798 DNA polymerase B region; PFAM: DNA-directed DNA polymerase, family B, conserved region; DNA-directed DNA polymerase, family B, exonuclease domain; SMART: DNA-directed DNA polymerase, family B; SPTR: DNA polymerase. | 0.419 |
EJG06094.1 | pcn | Metli_0116 | Metli_0896 | TIGRFAM: signal peptidase I, archaeal type; InterPro IPR001733; KEGG: mem:Memar_0046 peptidase S26B, signal peptidase; SPTR: Peptidase S26B, signal peptidase; TIGRFAM: Peptidase S26B, eukaryotic signal peptidase. | DNA polymerase sliding clamp; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. | 0.668 |
EJG06094.1 | priL | Metli_0116 | Metli_0897 | TIGRFAM: signal peptidase I, archaeal type; InterPro IPR001733; KEGG: mem:Memar_0046 peptidase S26B, signal peptidase; SPTR: Peptidase S26B, signal peptidase; TIGRFAM: Peptidase S26B, eukaryotic signal peptidase. | DNA primase, large subunit; Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair. | 0.579 |
EJG06094.1 | priS | Metli_0116 | Metli_1941 | TIGRFAM: signal peptidase I, archaeal type; InterPro IPR001733; KEGG: mem:Memar_0046 peptidase S26B, signal peptidase; SPTR: Peptidase S26B, signal peptidase; TIGRFAM: Peptidase S26B, eukaryotic signal peptidase. | DNA primase small subunit; Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. [...] | 0.659 |
EJG06094.1 | radA | Metli_0116 | Metli_1870 | TIGRFAM: signal peptidase I, archaeal type; InterPro IPR001733; KEGG: mem:Memar_0046 peptidase S26B, signal peptidase; SPTR: Peptidase S26B, signal peptidase; TIGRFAM: Peptidase S26B, eukaryotic signal peptidase. | DNA repair and recombination protein radA; Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules. | 0.408 |
EJG06094.1 | rnhB | Metli_0116 | Metli_1957 | TIGRFAM: signal peptidase I, archaeal type; InterPro IPR001733; KEGG: mem:Memar_0046 peptidase S26B, signal peptidase; SPTR: Peptidase S26B, signal peptidase; TIGRFAM: Peptidase S26B, eukaryotic signal peptidase. | Ribonuclease HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. | 0.869 |
EJG07089.1 | EJG06094.1 | Metli_1132 | Metli_0116 | PFAM: DNA polymerase family B; DNA polymerase family B, exonuclease domain; COGs: COG0417 DNA polymerase elongation subunit (family B); InterPro IPR006133:IPR006134:IPR006172; KEGG: mem:Memar_0798 DNA polymerase B region; PFAM: DNA-directed DNA polymerase, family B, conserved region; DNA-directed DNA polymerase, family B, exonuclease domain; SMART: DNA-directed DNA polymerase, family B; SPTR: DNA polymerase. | TIGRFAM: signal peptidase I, archaeal type; InterPro IPR001733; KEGG: mem:Memar_0046 peptidase S26B, signal peptidase; SPTR: Peptidase S26B, signal peptidase; TIGRFAM: Peptidase S26B, eukaryotic signal peptidase. | 0.419 |
EJG07089.1 | EJG08104.1 | Metli_1132 | Metli_2163 | PFAM: DNA polymerase family B; DNA polymerase family B, exonuclease domain; COGs: COG0417 DNA polymerase elongation subunit (family B); InterPro IPR006133:IPR006134:IPR006172; KEGG: mem:Memar_0798 DNA polymerase B region; PFAM: DNA-directed DNA polymerase, family B, conserved region; DNA-directed DNA polymerase, family B, exonuclease domain; SMART: DNA-directed DNA polymerase, family B; SPTR: DNA polymerase. | PFAM: RNase H; COGs: COG0328 Ribonuclease HI; InterPro IPR002156; KEGG: mem:Memar_0341 ribonuclease H; PFAM: Ribonuclease H; SPTR: Ribonuclease H. | 0.537 |
EJG07089.1 | fen | Metli_1132 | Metli_1878 | PFAM: DNA polymerase family B; DNA polymerase family B, exonuclease domain; COGs: COG0417 DNA polymerase elongation subunit (family B); InterPro IPR006133:IPR006134:IPR006172; KEGG: mem:Memar_0798 DNA polymerase B region; PFAM: DNA-directed DNA polymerase, family B, conserved region; DNA-directed DNA polymerase, family B, exonuclease domain; SMART: DNA-directed DNA polymerase, family B; SPTR: DNA polymerase. | Flap structure-specific endonuclease; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair [...] | 0.999 |
EJG07089.1 | pcn | Metli_1132 | Metli_0896 | PFAM: DNA polymerase family B; DNA polymerase family B, exonuclease domain; COGs: COG0417 DNA polymerase elongation subunit (family B); InterPro IPR006133:IPR006134:IPR006172; KEGG: mem:Memar_0798 DNA polymerase B region; PFAM: DNA-directed DNA polymerase, family B, conserved region; DNA-directed DNA polymerase, family B, exonuclease domain; SMART: DNA-directed DNA polymerase, family B; SPTR: DNA polymerase. | DNA polymerase sliding clamp; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. | 0.999 |
EJG07089.1 | priL | Metli_1132 | Metli_0897 | PFAM: DNA polymerase family B; DNA polymerase family B, exonuclease domain; COGs: COG0417 DNA polymerase elongation subunit (family B); InterPro IPR006133:IPR006134:IPR006172; KEGG: mem:Memar_0798 DNA polymerase B region; PFAM: DNA-directed DNA polymerase, family B, conserved region; DNA-directed DNA polymerase, family B, exonuclease domain; SMART: DNA-directed DNA polymerase, family B; SPTR: DNA polymerase. | DNA primase, large subunit; Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair. | 0.999 |
EJG07089.1 | priS | Metli_1132 | Metli_1941 | PFAM: DNA polymerase family B; DNA polymerase family B, exonuclease domain; COGs: COG0417 DNA polymerase elongation subunit (family B); InterPro IPR006133:IPR006134:IPR006172; KEGG: mem:Memar_0798 DNA polymerase B region; PFAM: DNA-directed DNA polymerase, family B, conserved region; DNA-directed DNA polymerase, family B, exonuclease domain; SMART: DNA-directed DNA polymerase, family B; SPTR: DNA polymerase. | DNA primase small subunit; Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. [...] | 0.999 |
EJG07089.1 | radA | Metli_1132 | Metli_1870 | PFAM: DNA polymerase family B; DNA polymerase family B, exonuclease domain; COGs: COG0417 DNA polymerase elongation subunit (family B); InterPro IPR006133:IPR006134:IPR006172; KEGG: mem:Memar_0798 DNA polymerase B region; PFAM: DNA-directed DNA polymerase, family B, conserved region; DNA-directed DNA polymerase, family B, exonuclease domain; SMART: DNA-directed DNA polymerase, family B; SPTR: DNA polymerase. | DNA repair and recombination protein radA; Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules. | 0.838 |
EJG07089.1 | rnhB | Metli_1132 | Metli_1957 | PFAM: DNA polymerase family B; DNA polymerase family B, exonuclease domain; COGs: COG0417 DNA polymerase elongation subunit (family B); InterPro IPR006133:IPR006134:IPR006172; KEGG: mem:Memar_0798 DNA polymerase B region; PFAM: DNA-directed DNA polymerase, family B, conserved region; DNA-directed DNA polymerase, family B, exonuclease domain; SMART: DNA-directed DNA polymerase, family B; SPTR: DNA polymerase. | Ribonuclease HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. | 0.855 |
EJG08104.1 | EJG07089.1 | Metli_2163 | Metli_1132 | PFAM: RNase H; COGs: COG0328 Ribonuclease HI; InterPro IPR002156; KEGG: mem:Memar_0341 ribonuclease H; PFAM: Ribonuclease H; SPTR: Ribonuclease H. | PFAM: DNA polymerase family B; DNA polymerase family B, exonuclease domain; COGs: COG0417 DNA polymerase elongation subunit (family B); InterPro IPR006133:IPR006134:IPR006172; KEGG: mem:Memar_0798 DNA polymerase B region; PFAM: DNA-directed DNA polymerase, family B, conserved region; DNA-directed DNA polymerase, family B, exonuclease domain; SMART: DNA-directed DNA polymerase, family B; SPTR: DNA polymerase. | 0.537 |
EJG08104.1 | fen | Metli_2163 | Metli_1878 | PFAM: RNase H; COGs: COG0328 Ribonuclease HI; InterPro IPR002156; KEGG: mem:Memar_0341 ribonuclease H; PFAM: Ribonuclease H; SPTR: Ribonuclease H. | Flap structure-specific endonuclease; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair [...] | 0.770 |
EJG08104.1 | pcn | Metli_2163 | Metli_0896 | PFAM: RNase H; COGs: COG0328 Ribonuclease HI; InterPro IPR002156; KEGG: mem:Memar_0341 ribonuclease H; PFAM: Ribonuclease H; SPTR: Ribonuclease H. | DNA polymerase sliding clamp; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. | 0.685 |
EJG08104.1 | rnhB | Metli_2163 | Metli_1957 | PFAM: RNase H; COGs: COG0328 Ribonuclease HI; InterPro IPR002156; KEGG: mem:Memar_0341 ribonuclease H; PFAM: Ribonuclease H; SPTR: Ribonuclease H. | Ribonuclease HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. | 0.880 |
EJG08104.1 | thyA | Metli_2163 | Metli_0429 | PFAM: RNase H; COGs: COG0328 Ribonuclease HI; InterPro IPR002156; KEGG: mem:Memar_0341 ribonuclease H; PFAM: Ribonuclease H; SPTR: Ribonuclease H. | Thymidylate synthase; May catalyze the biosynthesis of dTMP using an unknown cosubstrate; Belongs to the thymidylate synthase family. Archaeal-type ThyA subfamily. | 0.694 |
carS | priS | Metli_0930 | Metli_1941 | UPF0290 protein; Catalyzes the formation of CDP-2,3-bis-(O-geranylgeranyl)-sn- glycerol (CDP-archaeol) from 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1- phosphate (DGGGP) and CTP. This reaction is the third ether-bond- formation step in the biosynthesis of archaeal membrane lipids. | DNA primase small subunit; Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. [...] | 0.668 |